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Changes of intestinal microbiota in patients with colon cancer before and after chemotherapy and study of probiotic intervention.

ABSTRACT: Interventions: Chemotherapy +placebo group:placebo; Chemotherapy + Clostridium butyricum capsules group:Clostridium butyricum capsules Primary outcome(s): Intestinal flora;Nutrition index;Immune index Study Design: Randomized parallel controlled trial

DISEASE(S): Colon Cancer

PROVIDER: 2678004 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Changes of intestinal microbiota before and after operation in patients with colon cancer and its influencing factors

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Project description:Probiotic bacteria, specific representatives of bacterial species that are a common part of the human microbiota, are proposed to deliver health benefits to the consumer by modulation of intestinal function via largely unknown molecular mechanisms. To explore in vivo mucosal responses of healthy adults to probiotics, we obtained transcriptomes in an intervention study following a double-blind placebo-controlled cross-over design. In the mucosa of the proximal small intestine of healthy volunteers, probiotic strains from the species Lactobacillus acidophilus, L. casei and L. rhamnosus each induced differential gene regulatory networks and pathways in the human mucosa. Comprehensive analyses revealed that these transcriptional networks regulate major basal mucosal processes, and uncovered remarkable similarity to response profiles obtained for specific bioactive molecules and drugs. This study elucidates how intestinal mucosa of healthy humans perceive different probiotics and provides avenues for rationally designed tests of clinical applications. Keywords: mucosal response of healthy adult humans to lactic acid bacteria This study was set up according to a randomised double-blind cross-over placebo-controlled design. It contains transcriptional profiles from biopsies from 7 healthy individuals after oral intake of three different Lactobacillus species or placebo control. In total, this study includes data from 7 individuals x 4 treatments=28 arrays.

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Clostridium butyricum improves perioperative intestinal function and immune status in patients with colorectal cancer: a randomized controlled trial

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