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Effects of different volume treatment regimens on perioperative intestinal flora of patients undergoing pancreatic tumor surgery

ABSTRACT: Interventions: Group 1:adequate fluid supplementation;Group 2:GDFT Primary outcome(s): Diversity of intestinal flora Study Design: Parallel

DISEASE(S): Pancreatic Cancer

PROVIDER: 2695603 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Role of folic acid in regulating intestinal flora and short-chain fatty acids based on in vitro fermentation model

Project description:Folic acid deficiency is common worldwide and is linked to intestinal flora imbalance. The intestinal microbial utilization of folic acid based on model animals faces the challenges of repeatability and individual variability. In this study, we built an in vitro fecal slurry culture model deficient in folic acid. We examined the effects of supplementation with different forms of folic acid (5-methyltetrahydrofolate and non-reduced folic acid) on the modulation of intestinal flora. 16S rDNA gene sequencing showed alpha diversity increased after folic acid supplementation compared to fermentation samples with folic acid deficiency. In the non-reduced folic acid (FA) group, the relative abundance of the Firmicutes phylum dropped to 56.7%, whereas in the 5-methyltetrahydrofolate (MTHF) supplementation group, it grew to 64.9%. Lactobacillus genera became more prevalent, reaching 22.8% and 30.8%, respectively. Additionally, Bifidobacterium and Pedioccus, two common probiotic bacteria, were in higher abundance. Short-chain fatty acids (SCFAs) analysis showed that supplementation with folic acid (non-reduced folic acid, 5-methyltetrahydrofolate) decreased acetic acid and increased the fermentation yield of isobutyric acid. The in vitro fecal slurry culture model developed in this study can be utilized as a human folic acid deficiency model for studying intestinal microbiota and demonstrated that both 5-methyltetrahydrofolate and non-reduced folic acid have effects on the regulation of intestinal microecology.

2024-03-01 | GSE227224 | GEO

16s rDNA-sequencing of gastric flora in mice fed with high-salt diets

Project description:There are 10 mice in the experiment, named REC. The mice were fed with high salt diets (5% NaCl) for 4 weeks and then fed with normal salt diets for 4 weeks. Then extracted DNA from mice gastric flora to detect changes in the gastric flora of mice.

2019-07-13 | GSE134237 | GEO

Mice with and without enteric flora

Project description:Although microbiota plays a critical role for the normal development and function of host immune systems, the detail of the influence, especially on those in the large intestine (LI), remains unknown. Here, we performed transcriptome analysis using Affymetrix GeneChip on LI of germ-free (GF) and specific pathogen free (SPF) mice of IQI, an inbred strain established from ICR. Keywords: comparison of the mice with or without enteric flora

2007-06-06 | GSE8006 | GEO

Effect of bacteriocin NC8 on human intestinal flora

Project description:Herein, we evaluated the regulation of plantaricin NC8 on gut microbiota by in vitro simulation system, and assessed their modulation on different intestinal types, namely enterotype 1 (ET B) and enterotype 2 (ET P), for the first time. Plantaricin NC8 could not significantly promote or inhibit the production short chain fatty acids (SCFAs) by the gut flora in the fecal samples from eight subjects to produce through Gas chromatography (GC) determining, neither ET B nor ET P. 16S rDNA sequencing showed that plantaricin NC8 shortened the Shannon index of ET B and the Simpson index of ET P, but their β diversity change was not statistically significant. In addition, plantaricin NC8 could promote the growth of beneficial bacteria. Results showed that plantaricin NC8 mainly increased the abundance of Actinobacterias, Bacteroides, Bifidobacterium, Megamonas, Escherichia-Shigella, and decreased the abundance of Streptococcus in ET B. And it also increased the abundance of Prevotella_9, Bifidobacterium, Escherichia-Shigella, Mitsuokella and others in ET P. Plantaricin NC8 can influence intestinal microorganisms, but the influence were different for different enterotypes.

2022-03-30 | GSE199735 | GEO

Viscera flora

Project description:Viscera flora Raw sequence reads

| PRJNA819832 | ENA

The study of precise nutrition intervention for colorectal cancer targeting intestinal flora

Project description:Interventions: experimental group 1:Lycium barbarum polysaccharides;Experimental group 2:probiotics;experimental group 3:probiotics+ Lycium barbarum polysaccharides;Control group:placebo Primary outcome(s): Short chain fatty acids;IL-1 beta;IL-6;IL-4;IL-10;Immune interferon;tumor necrosis factor;MUC-2;Bcl-xL;NF-kB;IkB alpha;CRP;SIgA;postoperative abdominal pain;Flora richness;Flora diversity;Flora structure Study Design: Parallel

| 2696263 | ecrin-mdr-crc

South Australian Flora

Project description:South Australian Flora Raw sequence reads

| PRJNA665108 | ENA

Transcription profiling of faecal flora from healthy individuals and a patient with ulcerative colitis during disease and remission states

Project description:Comparison of faecal flora of three healthy individuals and a patient suffering from Ulcerative Colitis during disease and remission states. Faecal samples were taken and frozen at -80 within one hour.

2008-07-18 | E-MEXP-1395 | biostudies-arrayexpress

Lactobacillus from the Altered Schaedler Flora maintain IFNγ homeostasis to promote behavioral stress resilience.

Project description:The gut microbiome consists of trillions of bacteria, fungi, and viruses that inhabit the digestive tract. These communities are sensitive to disruption from environmental exposures ranging from diet changes to illness. Disruption of the community of lactic acid producing bacteria, Lactobaccillacea, has been well documented in mood disorders and stress exposure. In fact, oral supplement with many Lactobacillus species can ameliorate these effects, preventing depression- and anxiety-like behavior. Here, we utilize a gnotobiotic mouse colonized with the Altered Schaedler Flora to remove the two native species of Lactobaccillacea. Using this novel microbial community, we found that the Lactobacillus species themselves, and not the disrupted microbial communities are protective from environmental stressors. Further, we determine that Lactobaccillacea are maintaining homeostatic IFNγ levels which are mediating these behavioral and circuit level responses. By utilizing the Altered Schaedler Flora, we have gained new insight into how probiotics influence behavior and provide novel methods to study potential therapies to treat mood disorders.

2023-08-22 | GSE241110 | GEO

Flora

Project description:Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants

| PRJEB27325 | ENA

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