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Clinical molecular subtyping study based on precision Fusobacterium detection in colrectal cancer.

ABSTRACT: Interventions: Tumor tissue group and tumor-adjacent tissue group:Nil Primary outcome(s): Identification of clostridium species Study Design: Factorial

DISEASE(S): Colorectal Cancer

PROVIDER: 2696605 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Clinical molecular subtyping study based on precision Fusobacterium detection in colrectal cancer.

Project description:Interventions: CRC group:Nil;Healthy control group:Nil Primary outcome(s): Identification of clostridium species Study Design: Factorial

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Molecular Changes of Lung Malignancy in HIV Infection

Project description:To evaluate the molecular changes of lung malignancy in HIV infection, we analyzed the differential gene expression profiles and screened the early detection biomarkers of HIV-associated lung cancer using Affymetrix arrays. RNA was for transcriptomic profiles analysis in the HIV lung cancer tumor tissue samples from 3 patients with AC and 1 patient with squamous cell carcinoma (SCC) including 3 pairs of tumor/adjacent normal tissue paraffin specimens and 1 pair of tumor/adjacent normal fresh tissue samples.

2018-09-04 | GSE106937 | GEO

The Cancer-Associated Microbe Library reveals functional host-microbe interactions during colorectal cancer progression

Project description:<p>Functional characterization of microbes which colonize CRC is impeded by a lack of bacterial strains from tumor tissues. Here, we report the Cancer-Associated Microbe Library (CAM-L), comprising more than 3,000 viable bacterial isolates, representing 121 distinct species, and 60 matching organoid models from colorectal adenomas, adenocarcinomas, metastases, and adjacent tissue controls of 45 patients. CAM-L comprises 47 species not covered by large stool-based culture collections and two novel species of Fusobacterium and Granulicatella. In silico characterization reveals that CAM-L isolates encode a diversity of host-relevant functions that differ by disease state. We showcase the capacity for functional exploration with CAM-L isolates using three examples, covering adhesin variants of genotoxic Escherichia coli, bile salt deconjugation by metastasis-dwelling Enterococcus faecalis and glycoprotein modification by Clostridium perfringens. The CAM-L collection is set to help cancer microbiome research mature from association to systematic exploration of causality.</p>

2026-02-08 | MTBLS7385 | MetaboLights

Fusobacterium

Project description:Group of uncharacterized isolates

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Project description:Gut, blood, tumor adjacent tissue and tumor tissue mycobiome in brain tumors

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Project description:Gut, blood, tumor adjacent tissue and tumor tissue microbiome in brain tumors

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Multi-Omic Molecular Profiling of Lung Cancer Risk in Chronic Obstructive Pulmonary Disease

Project description:Chronic obstructive pulmonary disease (COPD) is a known risk factor for developing lung cancer suggesting that the COPD stroma contains factors supporting tumorigenesis. Since cancer initiation is complex we used a multi-omic approach to identify gene expression patterns that distinguish COPD stroma in patients with or without lung cancer. We obtained lung tissue from patients with COPD and lung cancer (tumor and adjacent non-malignant tissue) and those with COPD without lung cancer for proteomic and mRNA (cytoplasmic and polyribosomal) profiling. We used the joint and individual variation explained (JIVE) method to integrate and analysis across the three datasets. JIVE identified eight latent patterns that robustly distinguished and separated the three groups of tissue samples. Predictive variables that associated with the tumor, compared to adjacent stroma, were mainly represented in the transcriptomic data, whereas, predictive variables associated with adjacent tissue compared to controls was represented at the translatomic level. Kyoto Encyclopedia of Genes and Genome (KEGG) pathway analysis revealed extracellular matrix (ECM) and PI3K-Akt signaling pathways as important signals in the pre-malignant stroma. COPD stroma adjacent to lung cancer is unique and differs from non-malignant COPD tissue and is distinguished by the extracellular matrix and PI3K-Akt signaling pathways.

2018-10-05 | GSE106899 | GEO

Study on change of PBMC and tumor local immune map in colon cancer patients before and after general anesthesia based on single cell transcriptome sequencing

Project description:Interventions: Sevoflurane group:Nil;Propofol group:NIl Primary outcome(s): Heterogeneity of immune cell RNA spectrum in local tissue and peripheral blood of tumor Study Design: Non randomized control

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Native Index Ligation-Based Targeted Degradome Sequencing (NIL-TDS) for High Precision Quantification of small RNA Slicing Activity

Project description:NIL-TDS

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Intrahepatic Cholangiocarcinoma MSKCC

Project description:Cohort of primary tumor and tumor-adjacent non-malignant tissue from 142 intrahepatic cholangiocarcinoma patients and patient-derived xenografts.

2024-07-15 | MSV000095336 | MassIVE

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