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Study on the correlation between gene mutation and TCM syndrome types in metastatic colorectal cancer

ABSTRACT: Interventions: Deficiency syndrome vs positive syndrome:Nil Primary outcome(s): gene mutations Study Design: Factorial

DISEASE(S): Metastatic Colorectal Cancer

PROVIDER: 2699847 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Study on the Correlation Between Gene Mutation and TCM Syndrome Types in Metastatic Colorectal Cancer

Project description:To explore the correlation between gene mutations of metastatic colorectal cancer and TCM syndrome types based on Second-generation sequencing technology.

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Multi-group analysis of TCM syndrome types of patients with colorectal cancer

Project description:Interventions: Patients with spleen deficiency and qi stagnation syndrome SDQSS:NA;Patients with DHS with damp-heat accumulation syndrome:NA;Patients with SPOS with stasis and internal resistance syndrome:NA;Patients with SKYDS of Spleen and Kidney Yang Deficiency Syndrome:NA;Patients with liver-kidney yin deficiency syndrome LKYDS:NA;QBDS patients with deficiency of both qi and blood syndrome:NA Primary outcome(s): Serum metabolites;Fecal microbiome;lipidomics Study Design: Diagnostic test for accuracy

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Application of gut microbiota in dynamic evaluation of TCM syndromes and canceration in patient with colorectal tumor

Project description:Interventions: Colorectal adenoma (excessive syndrome: intestinal damp-heat syndrome) group:None;Colorectal adenoma (deficiency syndrome: spleen and stomach deficiency syndrome) group:None;Colorectal cancer (excessive syndrome: damp-heat accumulation syndrome) group:None;Colorectal cancer (deficiency syndrome: spleen deficiency and qi stagnation syndrome) group:None;Healthy control group:None Primary outcome(s): Gut microbiota Study Design: Factorial

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Effect of Supplementing Qi and strengthening spleen on the expression of TTR in serum of patients with colorectal carcinoma and its correlation with the dynamic changes of syndrome

Project description:Interventions: Syndrome of spleen qi deficiency1:Chinese medicine of Supplementing Qi and nourishing spleen;Syndrome of spleen qi deficiency2:no;Flat syndrome group:no;Qi deficiency constitution:no Primary outcome(s): Symptom score;Serum TTR expression Study Design: Case-Control study

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The intestinal microecology changes and metabonomics-based prognostic biomarkers screening in advanced colorectal cancer patients with qi deficiency syndrome

Project description:Interventions: Group1:Qi deficiency syndrome quantitative score>8;Group 2:Yin deficiency syndrome quantitative score>10;Group 3:deficiency syndrome quantitative score<3 with no obvious excess syndrome Primary outcome(s): serum metabonomics;Intestinal flora genome Study Design: Cohort study

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Comparative gene expression analysis between Nipponbare and 6-4 under two conditions

Project description:Nipponbare performs poorly in phosphorus (P) deficient soil whereas a Nipponbare-derived NIL containing the Pup1 allele of donor parent Kasalath is tolerant to P deficiency. In this experiment we compared gene expression patterns in roots of this NIL to Nipponbare, grown either in a P deficient or P fertilized soil. The aim is to separate constitutive differences in expression from those induced by P deficiency. Keywords: genotype comparison, constitutive differential expression

2009-10-31 | GSE6187 | GEO

Episignatures stratifying ADNP syndrome show modest correlation with phenotype [Methylation]

Project description:We conducted an independent study on 24 individuals with ADNP syndrome and replicated the existence of the two mutation-dependent ADNP episignatures. To probe whether the two distinct episignatures correlate with clinical outcomes, we used deep behavioral and neurobiological data from two prospective cohorts of individuals with a genetic diagnosis of ADNP syndrome.

2020-06-14 | GSE152427 | GEO

Gene expression in the mitochondrial syndrome of coenzyme Q deficiency

Project description:Coenzyme Q10 deficiency syndrome includes a clinically heterogeneous group of mitochondrial diseases characterized by low content of CoQ10 in tissues. The only currently available treatment is supplementation with CoQ10, which improves the clinical phenotype in some patients but does not reverse established damage. Incubation with CoQ10 restored respiration and apoptotic pathways but did not affect lipid metabolism, cell growth, and undifferentiated phenotype presented by CoQ10 deficient cells. We conclude that the mitochondrial dysfunction caused byCoQ10 deficiency induces a stable survival adaptation of somatic cells from patients, thus explaining their incomplete recovery after treatment. We compared the gene expresion of human dermal fibroblast from healthy people (group 1) with fibroblast from diferent patient diagnosed with the human syndrome of coenzyme Q10 deficiency, which were treated (group 3) or not (group 2) with coenzyme Q10 to recovery ATP levels.

2013-04-05 | E-GEOD-33940 | biostudies-arrayexpress

Correlation between preoperative dyslipidemia and perioperative neurocognitive impairment in elderly patients with colorectal cancer

Project description:Interventions: Dyslipidemia group:Nil;Normal blood lipid group:Nil Primary outcome(s): Minimum Mental State Examination (MMSE) Study Design: Factorial

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A novel GATA2 enhancer single nucleotide mutation results in the MonoMAC syndrome phenotype in two second cousins

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2023-10-31 | GSE227436 | GEO

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