Effect of dignity therapy on dignity and quality of life of colorectal cancer patients with colostomy
Ontology highlight
ABSTRACT:
DISEASE(S): Colorectal Cancer
PROVIDER: 37925 | ecrin-mdr-crc |
REPOSITORIES: ECRIN MDR
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Project description: Not available
| S-EPMC7709367 | biostudies-literature
Project description:Adult lung resident stem/progenitor cells, including P63+ progenitor cells, have demonstrated the capacity for regeneration of lung epithelium in precinical models. Here we report a clinical trial of intra-pulmonary P63+ progenitor cell transplantation which included 28 participants with chronic obstructive pulmonary disease (COPD) (stage II~IV). For control group, standard of care (SOC) for COPD treatment was given. For intervention group, in addition to SOC, autologous P63+ progenitor cells were isolated from the airway basal layer via bronchoscopic brushing, cultured for 3~5 weeks, and then transplanted into the lungs via bronchoscopy with 0.7-5.2x10^6 cells per kilogram bodyweight. Eventually 20 patients were evaluated (intervention group n=17; control group n=3). No grade 3~5 adverse events (AE) or serious adverse events occurred in any group. Bronchoscopy-associated AEs were recorded only in intervention groups, while the other AEs were recorded in both groups without showing significant difference. Participants in intervention group displayed significant improvement in diffusing capacity of the lung for carbon monoxide (DLCO) (change from baseline, 24 weeks: +18.2%), showing significant difference comparing to control group (change from baseline, 24 weeks: -17.4%)(p-value=0.008). Furthermore, more participants in intervention group showed > 30 m increase in walking distance within 6 minutes, demonstrating significant difference comparing to control group (p-value=0.036). Transcriptomic analysis of cells isolated from responding and non-responding individuals in the intervention group showed that higher expression of P63 and Nkx homeobox-1 was associated with better efficacy. In conclusion, transplantation of cultured P63+ lung progenitor cells was safe and represented a potential treatment strategy for COPD.
2024-01-20 | GSE236438 | GEO
Project description:Intervention 1: For intervention group, 4 sessions (two steps), foot reflexology massage (massage techniques and foot exercises) for 20 minutes, two weeks apart. Intervention 2: The control group will receive standard cares of center.;Lifestyle;Lifestyle;For intervention group, 4 sessions (two steps), foot reflexology massage (massage techniques and foot exercises) for 20 minutes, two weeks apart.;The control group will receive standard cares of center.
Primary outcome(s): Quality of life. Timepoint: Before the intervention and at the next session immediately before the intervention, the questionnaires will be completed by the test group. Method of measurement: European Organisation for Research and Treatment of Cancer quality of life questionnaries.
Study Design: Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive.
| 2492557 | ecrin-mdr-crc
Project description:In a randomized controlled trial, 82 older adults (>65y) with (or at risk of) undernutrition (n=82) were randomly allocated to 12 weeks of supplementation with a novel supplement (586 kcal, 22 g protein of which 50% whey and 50% casein, 206 mg ursolic acid, 7 g free BCAAs, 11 µg vitamin D) or standard care (600 kcal, 24g protein of which 100% casein, 4 µg vitamin D). Body weight increased significantly in the 12 weeks, both in the intervention group (+1.6 ± 0.2 kg, p<.0001) and in the standard care group (+1.8 ± 0.2 kg, p<.0001). Gait speed during 4m and 400m tests improved over time in the intervention group, whereas the standard care showed no improvements (time*treatment effects 400m: p=0.038 and 4m: p=0.048). Gene sets related to mitochondrial functioning were strongly upregulated in the participants receiving the intervention product. We showed that a novel oral nutritional supplement improves gait speed in older adults via improvements in mitochondrial functioning.
2021-04-06 | GSE136395 | GEO
Project description:Intervention 1: Intervention group: acceptance and commitment therapy enriched with compassion, 10 weekly sessions. Intervention 2: Control group: receive no treatment.
Primary outcome(s): Body image. Timepoint: Before and after treatment (2 months interval). Method of measurement: Multi-dimensional questionnaire of individual’s attitude about body image.;Cognitive-behavioral avoidance. Timepoint: before and after treatment (2 months interval). Method of measurement: Young-Rygh Avoidance Inventory.;Sexual satisfaction. Timepoint: before and after treatment (2 months interval). Method of measurement: Hudson Sexual Satisfaction Scale.
Study Design: Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Education/Guidance.
| 2502309 | ecrin-mdr-crc
Project description:Intervention 1: Intervention group: First, the pre-test will be done. The experimental group will participate in 8 sessions of group therapy managed by the researcher and with the presence of psychologists. The content of sessions is designed and implemented Based on the Snyder’s work. Then, the post-test will be done and the results of the pre-test and the post-test will be compared. Intervention 2: Control group: This group will not receive any intervention. The difference of the quality of life, compliance of the pre-test and the post-test will be measured and compared with each other.;Intervention group: First, the pre-test will be done. The experimental group will participate in 8 sessions of group therapy managed by the researcher and with the presence of psychologists. The content of sessions is designed and implemented Based on the Snyder’s work. Then, the post-test will be done and the results of the pre-test and the post-test will be compared.;Control group: This group will not receive any intervention. The difference of the quality of life, compliance of the pre-test and the post-test will be measured and compared with each other.
Primary outcome(s): Hope. Timepoint: Before intervention, after intervention. Method of measurement: Snyder’s Hope Scale.;Quality of life. Timepoint: Before intervention, after intervention. Method of measurement: QLQ-C30 Persian.
Study Design: Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Other design features: Random assignment of subjects into two groups: First, subjects’ names will be written randomly on paper according to odd and even numbers. then the subjects will be randomly divided into two groups of experimental and control.
| 2488738 | ecrin-mdr-crc
Project description:Intervention 1: Intervention group: The intervention is Polypill V, which includes aspirin (81 mg), valsartan (40 mg), atrostatin (20 mg) and hydrochlorothiazide (5.12 mg). This pill is produced Alborzl Company and is taken once a day after dinner. Intervention 2: Control group: patients are followed for cardiovascular events.
Primary outcome(s): Systolic and diastolic heart failure. Timepoint: 6 months and one year after the intervention. Method of measurement: Ecocardiography.;Symptomatic arrhythmia. Timepoint: 6 months and one year after the intervention. Method of measurement: Clinical symptoms, Ecocardiography.;Acute coronary syndromes. Timepoint: 6 months and one year after the intervention. Method of measurement: Ecocardiography.;Stroke. Timepoint: 6 months and one year after the intervention. Method of measurement: Brain CT scan.;Cardiovascular mortality. Timepoint: 6 months and one year after the intervention. Method of measurement: Death certificate.
Study Design: Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Stratified randomization is used for random allocation ofpatients. In breast cancer patients have three stratum : 1- The group that take anthracycline alone (60%) in which 78 people take drug and 78 people take usual care, 2- The group that take anthracycline and bevacizumab (20%) In this group, 26 people take drug and 26 people take usual care. 3 - The group that does not take anthracycline (20%) In this group, 26 people take drug and 26 people take usual care. In colon cancer patients have two stratum : 1 - Group that take chemotherapy (80%) In this group, 72 people take drug and 72 usual care. 2- Group that only undergoes surgery (20%) In this group, 18 people take drug and 18 people take usual care. Randomization is done using randomization software, the output of the software is from number 1 to 440, which indicates that each person who
| 2503026 | ecrin-mdr-crc
Project description:Interventions: Experimental group:Discharge preparation service;Control group:Usual care
Primary outcome(s): Discharge readiness;Quality of discharge guidance
Study Design: Parallel
| 38933 | ecrin-mdr-crc
Project description: Not available
| S-EPMC6060835 | biostudies-literature
Project description:Lean nonalcoholic fatty liver disease (NAFLD) is increasingly recognized as a distinct clinical phenotype with limited evidence for effective non-pharmacological interventions and unclear mechanistic pathways. Aerobic exercise is recommended for NAFLD management, yet its effects and underlying gut microbiota–mediated mechanisms in lean NAFLD remain insufficiently characterized. This study is based on a randomized controlled trial (ClinicalTrials.gov identifier: NCT04882644) in which 100 adults with lean NAFLD were randomly assigned to a 3-month aerobic exercise intervention or usual care. 63 paired fecal samples were collected at baseline and after intervention. Gut microbiota profiles were generated using 16S rRNA gene sequencing. The dataset includes processed taxonomic abundance tables derived from fecal samples collected before and after the intervention. These data were used to characterize exercise-induced alterations in gut microbial diversity, composition, and functional potential, and to explore interindividual heterogeneity in microbiota responses to aerobic exercise in lean NAFLD. The microbiome data deposited in this series support integrative analyses with clinical phenotypes and circulating metabolomic profiles, aiming to elucidate gut microbiota–associated mechanisms underlying the metabolic benefits of aerobic exercise in lean NAFLD.
2025-12-18 | GSE314066 | GEO