FOG-001 in Locally Advanced or Metastatic Solid Tumors
Ontology highlight
ABSTRACT:
DISEASE(S): Carcinoma,Colorectal Cancer,Lung Neoplasms,Neoplasms,Neoplasm Metastasis,Non-small Cell Carcinoma,Beta-catenin,Gastric Cancer,Colorectal Neoplasms,Carcinoma, Non-small-cell Lung,Stomach Neoplasms,Locally Advanced Solid Tumor,Non-small Cell Carcinoma Of Lung, Tnm Stage 4,Solid Tumor,Β-catenin,Adenomatous Polyposis Coli,Non-small Cell Lung Cancer Stage Iiib,Gastroesophageal-junction Cancer,Non-small Cell Lung Cancer (nsclc),Non-small Cell Lung Cancer Metastatic,Apc,Non-small Cell Lung Cancer,Wnt Pathway,Metastatic Cancer,Cancer
PROVIDER: 64556 | ecrin-mdr-crc |
REPOSITORIES: ECRIN MDR
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Project description:Background and study aims
Treatment in patients with advanced colorectal cancer, (CRC) non-small cell lung cancer (NSCLC) and soft tissue sarcoma (STS) represent a significant unmet need. Local thermal ablation of tumor tissue using techniques such as radiofrequency ablation (RFA) or stereotactic radiotherapy is an established treatment option for different tumors, in particular, CRC and NSCLC. There is strong nonclinical and early clinical evidence that combining thermal ablation with the investigational product, 1.0% IP-001 for Injection might be able to turn ‘cold’ tumors into ‘hot’ tumors, inducing a long-term systemic immune response mediated by the patient’s immunological defense system against any remaining tumor cells both at the site of the ablation treatment and those that are outside or distant from the treated area (known as the abscopal effect).
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2. Adding 1.0% IP-001 for Injection elicits a tumor-specific adaptive immune response
As a result, it is hypothesized that ablation + IP-001 can be deployed against a wide variety of tumor types to induce customized immune activation against a patient’s own, unique cancer.
Who can participate?
Adult patients with confirmed CRC, NSCLC, or STS
What does the study involve?
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