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At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

ABSTRACT: This clinical trial studies the effect of cancer directed therapy given at-home versus in the clinic for patients with cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Currently most drug-related cancer care is conducted in infusion centers or specialty hospitals, where patients spend many hours a day isolated from family, friends, and familiar surroundings. This separation adds to the physical, emotional, social, and financial burden for patients and their families. The logistics and costs of navigating cancer treatments have become a principal contributor to patients’ reduced quality of life. It is therefore important to reduce the burden of cancer in the lives of patients and their caregivers, and a vital aspect of this involves moving beyond traditional hospital and clinic-based care and evaluate innovative care delivery models with virtual capabilities. Providing cancer treatment at-home, versus in the clinic, may help reduce psychological and financial distress and increase treatment compliance, especially for marginalized patients and communities.

DISEASE(S): Breast Carcinoma,Carcinoma,Malignant Germ Cell Tumor,Anal Carcinoma,Glioblastoma,Cervical Carcinoma,Biliary Tract Carcinoma,Urinary Bladder Neoplasms,Breast Neoplasms,Pancreatic Carcinoma,Colorectal Carcinoma,Lung Small Cell Carcinoma,Gastric Carcinoma,Ovarian Carcinoma,Carcinoma, Small Cell,Colorectal Neoplasms,Lung Carcinoma,Pancreatic Neoplasms,Stomach Neoplasms,Bladder Carcinoma,Carcinoid Tumor,Small Cell Lung Carcinoma,Advanced Malignant Solid Neoplasm,Neuroendocrine Carcinoma,Head And Neck Carcinoma,Prostate Small Cell Neuroendocrine Carcinoma,Carcinoma, Neuroendocrine,Her2-positive Breast Carcinoma,Prostate Carcinoma

PROVIDER: 68172 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Project description:Predicting Outcomes of Prostate Cancer Immunotherapyby Personalized Mathematical Models Natalie Kronik1¤, Yuri Kogan1, Moran Elishmereni1, Karin Halevi-Tobias1, Stanimir Vuk-Pavlovic ́2.,Zvia Agur1*.1Institute for Medical BioMathematics, Bene Ataroth, Israel,2College of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America Abstract Background:Therapeutic vaccination against disseminated prostate cancer (PCa) is partially effective in some PCa patients.We hypothesized that the efficacy of treatment will be enhanced by individualized vaccination regimens tailored by simplemathematical models.Methodology/Principal Findings:We developed a general mathematical model encompassing the basic interactions of avaccine, immune system and PCa cells, and validated it by the results of a clinical trial testing an allogeneic PCa whole-cellvaccine. For model validation in the absence of any other pertinent marker, we used the clinically measured changes inprostate-specific antigen (PSA) levels as a correlate of tumor burden. Up to 26 PSA levels measured per patient were dividedinto each patient’s training set and his validation set. The training set, used for model personalization, contained thepatient’s initial sequence of PSA levels; the validation set contained his subsequent PSA data points. Personalized modelswere simulated to predict changes in tumor burden and PSA levels and predictions were compared to the validation set.The model accurately predicted PSA levels over the entire measured period in 12 of the 15 vaccination-responsive patients(the coefficient of determination between the predicted and observed PSA values wasR2= 0.972). The model could notaccount for the inconsistent changes in PSA levels in 3 of the 15 responsive patients at the end of treatment. Each validatedpersonalized model was simulated under many hypothetical immunotherapy protocols to suggest alternative vaccinationregimens. Personalized regimens predicted to enhance the effects of therapy differed among the patients.Conclusions/Significance:Using a few initial measurements, we constructed robust patient-specific models of PCaimmunotherapy, which were retrospectively validated by clinical trial results. Our results emphasize the potential value andfeasibility of individualized model-suggested immunotherapy protocols.

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At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

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