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Impact of malnutrition diagnosed on clinical outcomes of postoperative patients with gastrointestinal tumors

ABSTRACT: Interventions: Case series:None Primary outcome(s): Overall survival;Length of hospital stay;Length of ICU stay;Hospital costs of this hospitalization;Infection complications;Non-infectious complications Study Design: Cohort study

DISEASE(S): Gastric Cancer, Colorectal Cancer

PROVIDER: 80798 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Investigation on Nutrition Status and its Clinical Outcome of Common Cancers

Project description:Interventions: Case series:Non-intervention Primary outcome(s): Patient Generated-Subjective Global Assessment;Karnofsky Performance Status (KPS) questionnaire;Quality of life questionnaire for cancer patients;Died in the 30 days within this hospitalization;Length of hospital stay;Length of ICU stay;Hospital costs of this hospitalization;Overall survival Study Design: Cohort study

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Genome-wide blood transcriptional profiling in critically ill patients - MARS consortium

Project description:The host response in critically ill patients with sepsis, septic shock remains poorly defined. Considerable research has been conducted to accurately distinguish patients with sepsis from those with non-infectious causes of disease. Technological innovations have positioned systems biology at the forefront of biomarker discovery. Analysis of the whole-blood leukocyte transcriptome enables the assessment of thousands of molecular signals beyond simply measuring several proteins in plasma, which for use as biomarkers is important since combinations of biomarkers likely provide more diagnostic accuracy than the measurement of single ones or a few. Evidence suggests that genome-wide transcriptional profiling of blood leukocytes can assist in differentiating between infection and non-infectious causes of severe disease. Of importance, RNA biomarkers have the potential advantage that they can be measured reliably in rapid quantitative reverse transcriptase polymerase chain reaction (qRT-PCR)-based point of care tests. PAXgene blood RNA was isolated at intensive-care unit (ICU) admission and throughout ICU length-of-stay. Through the use of genome-wide microarrays we aimed to identify molecular features that enbale the adequate discrimination of infectious and non-infectious sources of critical illness. Moreover, biological pathway analysis was used to tease out the most relevant biological units in sepsis and septic shock.

2015-07-06 | E-GEOD-65682 | biostudies-arrayexpress

The impact of pre-operative education on post-operative outcomes in patients with colorectal cancer in Johannesburg, South Africa

Project description:Interventions: Control group;Intervention group one;Intervention group two Primary outcome(s): ICU length of stay;Survival;Hospital length of stay;Post-operative complications Study Design: Factorial: participants randomly allocated to either no, one, some or all interventions simultaneously,Randomised,Stratified allocation where factors such as age, gender, center, or previous treatment are used in the stratification,Sealed opaque envelopes

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Development and validation intelligence assessment models for intestinal motility recovery after colorectal cancer surgery

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Impact of Probiotics on the Intestinal Microbiota

Project description:The purpose of this study is to assess the impact of probiotic administration (Saccharomyces boulardii) on patients undergoing colorectal resections comparing to the routine protocol by assessing: (1)intestinal microbiota modulation using RT-PCR to measure cytokine in the mucosa; (2) assess postoperative complications, mainly infectious and mortality, as well as length of hospital stay

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Effects of steroids on peripheral blood gene expression in COVID-19 patients according to rs1990760 variants

Project description:Background: Outcomes in patients with severe SARS-CoV-2 infection (COVID-19) are conditioned by viral control and regulation of inflammation. Variants in IFIH1, a gene coding the cytoplasmatic RNA sensor MDA5, regulate the response to viral infections. Methods: Patients admitted to an intensive care unit (ICU) with documented COVID-19 were prospectively included and IFIH1 rs1990760 genotypes determined. Peripheral blood gene expression, cell populations and immune mediators were measured during the first day after ICU admission before steroid therapy. Peripheral blood mononuclear cells from healthy volunteers were exposed ex-vivo to an MDA5 agonist and dexamethasone, and changes in gene expression assessed. ICU discharge and hospital death were modelled using rs1990760 variants and dexamethasone therapy as factors. Findings: 237 patients were studied. Patients with the IFIH1 rs1990760 TT variant showed a decrease in expression of inflammation-related pathways, an anti-inflammatory cell profile and a decrease in pro-inflammatory mediators. Cells with TT variant exposed to an MDA5 agonist ex-vivo showed an increase in FOXO3 and IL6 when dexamethasone was added. All patients with the TT variant not treated with steroids (n=14) survived their ICU stay (HR 2.49 95% confidence interval 1.29 – 4.79). Dexamethasone therapy in this subgroup (N=50) delayed ICU discharge and increased hospital mortality (HR 2.19, 95% confidence interval 1.01 – 4.87) and serum IL-6 concentrations. Interpretation: COVID-19 ICU patients with the IFIH1 rs1990760 TT variant show an ameliorated inflammatory response that results in better outcomes than CC/CT variants. Dexamethasone can reverse this anti-inflammatory phenotype, worsening the outcome. Funding: Instituto de Salud Carlos III.

2021-07-03 | GSE177025 | GEO

Peripheral blood gene expression according to IFIH1 rs1990760 variants in critically-ill COVID-19 patients

2021-07-03 | GSE168400 | GEO

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Deep transcriptomics analysis reveals the development of postoperative ileus and the therapeutic effect of electroacupuncture

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2024-01-27 | GSE164909 | GEO

A RANDOMIZED, CONTROLLED, CLINICAL TRIAL TO COMPARE PERIPHERAL PARENTERAL NUTRITION (PeriOlimel N4-E) VS CONVENTIONAL FLUID THERAPY IN ENHANCED RECOVERY AFTER SURGERY (ERAS) PROTOCOL IN COLORECTAL CANCER SURGERY.

Project description:Primary objectives: The main objective is to determine if perioperative nutritional support with PeriOlimel N4-E, that reaches nutritional requirements of ERAS protocol for colorectal cancer surgery patients, can improve nutritional status so it decreases postoperative complications, hospital length of stay and costs, compared to conventional fluid therapy administration since patients receive oral nutrition at day 3-5. Primary endpoints: We set the primary endpoint as the presence of surgical postoperative complications during the first postoperative month.

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