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Machine learning-based noninvasive assays explore the use of volatile organic compounds for clinical diagnosis and evaluation of gastrointestinal tumors

ABSTRACT: Interventions: Gold Standard:pathological diagnosis ;Index test:Volatile organic compounds detected by gas chromatography-mass spectrometer and gas chromatography-ion migration spectrometry Primary outcome(s): Volatile organic compounds;sensitivity;specificity Study Design: Diagnostic test for accuracy

DISEASE(S): Stomach Cancer,Colorectal Cancer

PROVIDER: 89221 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Distinct emissions of biogenic volatile organic compounds from temperate benthic taxa

Project description:Output chromatography files from GCxGC-TOFMS analysis of volatile organic compounds from a temperate coral and macroalgae species found in Sydney, Australia.

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Exploiting volatile organic compounds as eco-friendly alternatives against the phytopathogenic fungus Thielaviopsis ethacetica

Project description:In this study, we showed that three bacteria were able to inhibit the mycelial growth of the phytopathogenic fungus Thielaviopsis ethacetica, by the emission of microbial volatile organic compounds (mVOCs). Aiming to understand the molecular mechanisms of these interactions, we evaluated the transcriptomic response of T. ethacetica to the mVOCs produced by one of these bacterial isolates.

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Volatile Organic Compounds (VOCs) Profile in Colorectal Cancer Patients and Healthy Controls.

Project description:Volatile organic compounds (VOCs) are low molecular weight (<1 kDa) compounds which represent the final products of cell metabolism. Their composition can be affected by several factors including diet, hormones, environment and the presence of diseases, in particular, cancer. Colorectal cancer (CRC) is one of the commonest tumours and is an important cause of cancer-related mortality. The expression of VOCs in breath that are linked to a patient’s disease state could offers a powerful, non-invasive approach to identifying CRC patients.

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Transcriptome analysis of Fusarium solani (NK-NH1) before and after inhibition of volatile organic compounds produced by Xenorhabdus bovienii

Project description:In order to study the inhibition mechanism of volatile organic compounds produced by Xenorhabdus bovienii on Fusarium solani (NK-NH1), we selected the inhibited and uninhibited Fusarium solani mycelia for transcriptome sequencing, and tried to find the corresponding inhibition mechanism at the gene level.

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The effect of CPPU on volatile compounds and transcriptome analysis of ‘Shine Muscat’ berries

Project description:Grape volatiles include a great number of compounds, among which monoterpenes, alcohols,esters and carbonyls were found.Grape may be divided into aromatic and non-aromatic varieties. ‘Shine Muscat’ belongs to the aromatic cultivar. The most abundant free compounds detected in Muscat grape were linalool, geraniol, citronellol, nerol. Grapevine (Vitis vinifera L.) is an economically important and widely cultivated fruit crop. Grape quality is important for its market value and is largely decided by its taste and aroma.Gas-chromatograph mass-spectrometry (GC-MS) was performed to observe changes of the volatile compounds.

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Microarray analysis of leaves of Arabidopsis thaliana Col-0 plants exposed to volatile pinenes (treatment) or hexane (control)

Project description:Volatile organic compounds (VOCs) may play a role in systemic acquired resistance (SAR), a salicylic acid (SA)-associated, broad-spectrum immune response in systemic, healthy tissues of locally infected plants. Four-to-five-week-old plants were exposed for three days to a mixture of volatile pinenes to investigate genome-wide transcriptional responses relative to hexane-treated control plants.

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Volatile compounds emitted by Plant Growth Promoting Fungi Tolypocladium inflatum GT22 alleviates copper and pathogen stress

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Volatile communication in plants relies on a KAI2-mediated signaling pathway

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2024-02-07 | GSE245080 | GEO

Exploiting volatile organic compounds as eco-friendly alternatives against the phytopathogenic fungus Thielaviopsis ethacetica

Project description:Exploiting volatile organic compounds as eco-friendly alternatives against the phytopathogenic fungus Thielaviopsis ethacetica

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Activation of defense pathways in Scots pine bark after feeding by Pine Weevil (Hylobius abietis)

Project description:Coniferous trees use the oleoresin, a mixture of non-volatile non-volatile diterpene acids and a large (20-50%) volatile fraction of mono- and sesquiterpenes, as a defence tool against damaging herbivores and pathogens. Volatilization of monoterpenes increases viscosity of oleoresin and finally leading to polymerization of resin and a formation of protective solid plug. Resin storing conifers form an important source of volatile organic compounds (VOCs) mainly dominated by volatile monoterpenes. In the atmosphere, conifer VOCs react with ozone and OH and nitrous oxide radicals forming secondary organic compounds. This project seeks a better understanding of the genetic control of conifer defences and the role of monoterpenoid compounds under biotic stresses.

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