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Chemerin in Colorectal Cancer and Its Relationship With Diet Quality

ABSTRACT: To investigate the relationship between serum chemerin levels of individuals with colorectal cancer and systematic inflammatory response parameters such as C-reactive protein(CRP) and albumin, and to investigate the relationship of these biomarkers with dietary inflammatory index, phytochemical, anthropometric measurements, and dietary inflammatory index, which is calculated with the data obtained from the 24-hour food consumption record and food consumption frequency questionnaire. The aim of this study is to examine the relationships between the index and dietary antioxidant capacity and to compare them with those of healthy individuals.

DISEASE(S): Nutrition Aspect Of Cancer,Diet Habit,Colorectal Cancer,Colorectal Neoplasms,Diet, Healthy

PROVIDER: 90484 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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An internal nutrient sensor detects specific dietary amino acids and promotes food consumption in Drosophila

Project description:Adequate protein intake is crucial for animals. Despite the recent progress in understanding protein hunger and satiety in the fruit fly Drosophila melanogaster, how fruit flies assess prospective dietary protein sources and ensure protein consumption remains elusive. We show here that three specific amino acids, L-glutamate (L-Glu), L-alanine (L-Ala), and L-aspartate (L-Asp), but not the D-enantiomers, rapidly promote food consumption in fruit flies when present in food. The effect of dietary amino acids to promote food consumption is independent of mating experience and internal nutritional status. Calcium imaging experiments show that six brain neurons expressing diuretic hormone 44 (DH44) can be rapidly and directly activated by these three amino acids during feeding. Genetic analysis shows that DH44+ neurons are both necessary and sufficient for dietary amino acids to promote food consumption. By conducting single cell RNAseq analysis, we also identify a amino acid transporter, CG13248, which is highly expressed in DH44+ neurons and is required for dietary amino acids to promote food consumption. Therefore, these data suggest that dietary amino acids may enter DH44+ neurons via CG13248 and modulate their activity and hence food consumption. Taken together, these data identify an internal amino acid sensor in the fly brain that evaluate food sources post-ingestively and facilitates adequate protein intake. These results shed critical light on the regulation of protein homeostasis at organismal levels by the nervous system.

2018-05-04 | GSE113990 | GEO

Inflammatory markers and frailty in home-dwelling elderly, a cross-sectional study

Project description:Low-grade, chronic inflammation during ageing (“inflammageing”) is suggested to be involved in the development of frailty in older age. However, studies on the association between frailty, using the frailty index definition, and inflammatory markers are limited. The aim of this study was to investigate the relationship between inflammatory markers and frailty index (FI) in older, home-dwelling adults. Home-dwelling men and women aged ≥ 70 years old, living in South-East Norway were recruited and included in a cross-sectional study. The FI used in the current study was developed according to Rockwood’s frailty index and included 38 variables, resulting in an FI score between 0 and 1 for each participant. Circulating inflammatory markers (IL-6, CRP, IGF-1, cystatin C, cathepsin S, and glycoprotein Acetyls) were analyzed from non-fasting blood samples using ELISA. Whole-genome PBMC transcriptomics was used to study the association between FI score and inflammation. The present study was a cross-sectional study that included home-dwelling men and women aged ≥ 70 years old, living in the Skedsmo area, South-East Norway. The study was conducted in 2014/2015 and has been described previously [Ottestad I, Ulven SM, Øyri LKL, Sandvei KS, Gjevestad GO, Bye A, et al. Reduced plasma concentration of branched-chain amino acids in sarcopenic older subjects: a cross-sectional study. Br J Nutr. 2018;120(4):445-53]. The participants were recruited by the National Register and received an invitation letter by mail. Briefly, a total of 2820 subjects were invited, and 437 subjects participated in the study. The participants met for a single study visit, and data was collected on dietary intake, body weight and composition, physical performance, medical history, cognitive function, risk of malnutrition, anthropometric measurements, blood pressure, heart rate, and quality of life. Non-fasting blood samples were also collected.

2023-09-01 | GSE236927 | GEO

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2022-02-23 | PXD012112 | Pride

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2018-07-18 | PXD009603 | Pride

BIOPROSPECTING OF KEFIR: SEARCH FOR BIOACTIVE PEPTIDES BY PROTEOMICS AND EVALUATION OF THEIR EFFECTS IN THE CARDIOVASCULAR SYSTEM OF HYPERTENSIVE ANIMALS

Project description:Kefir is a milk fermented by microorganisms with probiotic potential. Its consumption is associated with several beneficial effects, from antibacterial, healing, antioxidant, anti-inflammatory, anti-allergic, plasma glucose and cholesterol control to antitumor and antihypertensive activities. Despite its great potential, little is known about the bioactive molecules responsible for these actions. Therefore, the present project aims to perform the proteomic study of Kefir and its grain used for the milk fermentation aiming to identify the bioactive peptides, in particular those peptides with action in the cardiovascular system.

2019-12-16 | PXD012074 | JPOST Repository

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Project description:Mammalian feces can be collected non-invasively during field research and provides valuable information on the ecology and evolution of the host individuals. Undigested food objects, genome/metagenome, steroid hormones, and stable isotopes obtained from fecal samples provide evidence on diet, host/symbiont genetics, and physiological status of the individuals. However, proteins in mammalian feces have hardly been studied, which hampers the molecular investigations into the behavior and physiology of the host individuals. Here, we apply mass spectrometry-based proteomics to fecal samples (n = 10) that were collected from infant, juvenile, and adult captive Japanese macaques (Macaca fuscata) to describe the proteomes of the host, food, and intestinal microbes. The results show that fecal proteomics is a useful method to investigate dietary changes along with breastfeeding and weaning, to reveal the organ/tissue and taxonomy of dietary items, and to estimate physiological status inside intestinal tracts. These types of insights are difficult or impossible to obtain through other molecular approaches. Most mammalian species are facing extinction risk and there is an urgent need to obtain knowledge on their ecology and evolution for better conservation strategy. The fecal proteomics framework we present here is easily applicable to wild settings and other mammalian species, and provides direct evidence of their behavior and physiology.

2021-03-18 | PXD021098 | Pride

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2011-09-29 | E-GEOD-24432 | biostudies-arrayexpress

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Project description:Food composition of diets strongly determines the risk of experiencing inflammation related metabolic or cardiovascular disease. We aimed to determine the extent of inheritance of inflammatory responses to isocaloric changes in food composition as a prerequisite of personalized dietary recommendations in human twins.

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2011-08-31 | E-GEOD-28070 | biostudies-arrayexpress

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Project description:The typical human diet differs substantially in a number of ways from that of other primates. For instance, although many humans consume meat on a regular basis, non-human primate diets are typically dominated by plant foods. In addition, most human populations cook the majority of their foods, whereas all other free-living primate species eat exclusively raw diets. Such differences in food substrates and food processing are hypothesized to exert a large influence on metabolism. If maintained over evolutionary timescales, dietary differences may have contributed to shaping important human-specific features. To index the effect of food substrate and food preparation on metabolism we measured liver gene expression in mice fed diets of meat or tubers served either raw or cooked.

2016-03-08 | E-MTAB-1741 | biostudies-arrayexpress

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