Genomics

Dataset Information

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Wellcome Trust Case Control Consortium Data Access Committee

ABSTRACT: Access to summary data and individual-level genotype data is available by application to the Wellcome Trust Case Control Consortium Data Access Committee (CDAC). Access to data will be granted to qualified investigators for appropriate use. The CDAC also controls the individual level genotype data for the 1958 British Birth Cohort samples. For further guidelines, application form and data access agreement, please follow the link below.

PROVIDER: EGAC00000000001 | EGA |

REPOSITORIES: EGA

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Publications

Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis.

Fakiola Michaela M   Strange Amy A   Cordell Heather J HJ   Miller E Nancy EN   Pirinen Matti M   Su Zhan Z   Mishra Anshuman A   Mehrotra Sanjana S   Monteiro Gloria R GR   Band Gavin G   Bellenguez Céline C   Dronov Serge S   Edkins Sarah S   Freeman Colin C   Giannoulatou Eleni E   Gray Emma E   Hunt Sarah E SE   Lacerda Henio G HG   Langford Cordelia C   Pearson Richard R   Pontes Núbia N NN   Rai Madhukar M   Singh Shri P SP   Smith Linda L   Sousa Olivia O   Vukcevic Damjan D   Bramon Elvira E   Brown Matthew A MA   Casas Juan P JP   Corvin Aiden A   Duncanson Audrey A   Jankowski Janusz J   Markus Hugh S HS   Mathew Christopher G CG   Palmer Colin N A CN   Plomin Robert R   Rautanen Anna A   Sawcer Stephen J SJ   Trembath Richard C RC   Viswanathan Ananth C AC   Wood Nicholas W NW   Wilson Mary E ME   Deloukas Panos P   Peltonen Leena L   Christiansen Frank F   Witt Campbell C   Jeronimo Selma M B SM   Sundar Shyam S   Spencer Chris C A CC   Blackwell Jenefer M JM   Donnelly Peter P  

Nature genetics 20130106 2

To identify susceptibility loci for visceral leishmaniasis, we undertook genome-wide association studies in two populations: 989 cases and 1,089 controls from India and 357 cases in 308 Brazilian families (1,970 individuals). The HLA-DRB1-HLA-DQA1 locus was the only region to show strong evidence of association in both populations. Replication at this region was undertaken in a second Indian population comprising 941 cases and 990 controls, and combined analysis across the three cohorts for rs92  ...[more]

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