Genomics

Dataset Information

0

Unige T21


ABSTRACT: Data Access Committee EGAC00001000269

ORGANISM(S): Homo sapiens  

PROVIDER: EGAC00001000269 | EGA |

REPOSITORIES: EGA

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Publications


The study of gene expression in mammalian single cells via genomic technologies now provides the possibility to investigate the patterns of allelic gene expression. We used single-cell RNA sequencing to detect the allele-specific mRNA level in 203 single human primary fibroblasts over 133,633 unique heterozygous single-nucleotide variants (hetSNVs). We observed that at the snapshot of analyses, each cell contained mostly transcripts from one allele from the majority of genes; indeed, 76.4% of th  ...[more]

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