Genomics

Dataset Information

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EPIGEN-Brasil Data Access Committee


ABSTRACT: Data Access Committee EGAC00001000330

PROVIDER: EGAC00001000330 | EGA |

REPOSITORIES: EGA

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Publications

Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations.

Kehdy Fernanda S G FS   Gouveia Mateus H MH   Machado Moara M   Magalhães Wagner C S WC   Horimoto Andrea R AR   Horta Bernardo L BL   Moreira Rennan G RG   Leal Thiago P TP   Scliar Marilia O MO   Soares-Souza Giordano B GB   Rodrigues-Soares Fernanda F   Araújo Gilderlanio S GS   Zamudio Roxana R   Sant Anna Hanaisa P HP   Santos Hadassa C HC   Duarte Nubia E NE   Fiaccone Rosemeire L RL   Figueiredo Camila A CA   Silva Thiago M TM   Costa Gustavo N O GN   Beleza Sandra S   Berg Douglas E DE   Cabrera Lilia L   Debortoli Guilherme G   Duarte Denise D   Ghirotto Silvia S   Gilman Robert H RH   Gonçalves Vanessa F VF   Marrero Andrea R AR   Muniz Yara C YC   Weissensteiner Hansi H   Yeager Meredith M   Rodrigues Laura C LC   Barreto Mauricio L ML   Lima-Costa M Fernanda MF   Pereira Alexandre C AC   Rodrigues Maíra R MR   Tarazona-Santos Eduardo E  

Proceedings of the National Academy of Sciences of the United States of America 20150629 28


While South Americans are underrepresented in human genomic diversity studies, Brazil has been a classical model for population genetics studies on admixture. We present the results of the EPIGEN Brazil Initiative, the most comprehensive up-to-date genomic analysis of any Latin-American population. A population-based genome-wide analysis of 6,487 individuals was performed in the context of worldwide genomic diversity to elucidate how ancestry, kinship, and inbreeding interact in three population  ...[more]

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