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Leucocyte eQTLs in autoimmune disease and health

ABSTRACT: Data Access Committee EGAC00001000338

PROVIDER: EGAC00001000338 | EGA |

REPOSITORIES: EGA

ACCESS DATA

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Publications

Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease.

Peters James E JE Lyons Paul A PA Lee James C JC Richard Arianne C AC Fortune Mary D MD Newcombe Paul J PJ Richardson Sylvia S Smith Kenneth G C KG

PLoS genetics 20160325 3

Genome-wide association studies (GWAS) have transformed our understanding of the genetics of complex traits such as autoimmune diseases, but how risk variants contribute to pathogenesis remains largely unknown. Identifying genetic variants that affect gene expression (expression quantitative trait loci, or eQTLs) is crucial to addressing this. eQTLs vary between tissues and following in vitro cellular activation, but have not been examined in the context of human inflammatory diseases. We perfor ...[more]

PMID: 27015630

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