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GBM-ZEB1 Data Access Committee

ABSTRACT: Data Access Committee EGAC00001000354

PROVIDER: EGAC00001000354 | EGA |

REPOSITORIES: EGA

ACCESS DATA

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Publications

Prognostic Relevance of Tumor Purity and Interaction with MGMT Methylation in Glioblastoma.

Schulze Heuling Eva E Knab Felix F Radke Josefine J Eskilsson Eskil E Martinez-Ledesma Emmanuel E Koch Arend A Czabanka Marcus M Dieterich Christoph C Verhaak Roel G RG Harms Christoph C Euskirchen Philipp P

Molecular cancer research : MCR 20170201 5

Promoter methylation status of O-6-methylguanine-DNA methyltransferase (MGMT), a DNA repair enzyme, is a critical biomarker in glioblastoma (GBM), as treatment decisions and clinical trial inclusion rely on its accurate assessment. However, interpretation of results is complicated by poor interassay reproducibility as well as a weak correlation between methylation status and expression levels of MGMT. This study systematically investigates the influence of tumor purity on tissue subjected to MGM ...[more]

PMID: 28148826

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