Genomics

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Data Access Committee for the Metastatic Breast Cancer Whole-exome sequencing study

ABSTRACT: Data Access Committee EGAC00001000434

PROVIDER: EGAC00001000434 | EGA |

REPOSITORIES: EGA

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Publications

Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis.

Lefebvre Celine C   Bachelot Thomas T   Filleron Thomas T   Pedrero Marion M   Campone Mario M   Soria Jean-Charles JC   Massard Christophe C   Lévy Christelle C   Arnedos Monica M   Lacroix-Triki Magali M   Garrabey Julie J   Boursin Yannick Y   Deloger Marc M   Fu Yu Y   Commo Frédéric F   Scott Véronique V   Lacroix Ludovic L   Dieci Maria Vittoria MV   Kamal Maud M   Diéras Véronique V   Gonçalves Anthony A   Ferrerro Jean-Marc JM   Romieu Gilles G   Vanlemmens Laurence L   Mouret Reynier Marie-Ange MA   Théry Jean-Christophe JC   Le Du Fanny F   Guiu Séverine S   Dalenc Florence F   Clapisson Gilles G   Bonnefoi Hervé H   Jimenez Marta M   Le Tourneau Christophe C   André Fabrice F  

PLoS medicine 20161227 12

<h4>Background</h4>Major advances have been achieved in the characterization of early breast cancer (eBC) genomic profiles. Metastatic breast cancer (mBC) is associated with poor outcomes, yet limited information is available on the genomic profile of this disease. This study aims to decipher mutational profiles of mBC using next-generation sequencing.<h4>Methods and findings</h4>Whole-exome sequencing was performed on 216 tumor-blood pairs from mBC patients who underwent a biopsy in the context  ...[more]

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