Genomics,Multiomics

Dataset Information

0

AMC Macrophage Data Access Committee


ABSTRACT: Data Access Committee EGAC00001001123

OTHER RELATED OMICS DATASETS IN: E-MTAB-10431

ORGANISM(S): Homo sapiens  

PROVIDER: EGAC00001001123 | EGA |

REPOSITORIES: EGA

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Publications

Meta-Analysis of in vitro-Differentiated Macrophages Identifies Transcriptomic Signatures That Classify Disease Macrophages in vivo.

Chen Hung-Jen HJ   Li Yim Andrew Y F AYF   Griffith Guillermo R GR   de Jonge Wouter J WJ   Mannens Marcel M A M MMAM   Ferrero Enrico E   Henneman Peter P   de Winther Menno P J MPJ  

Frontiers in immunology 20191211


Macrophages are heterogeneous leukocytes regulated in a tissue- and disease-specific context. While in vitro macrophage models have been used to study diseases empirically, a systematic analysis of the transcriptome thereof is lacking. Here, we acquired gene expression data from eight commonly-used in vitro macrophage models to perform a meta-analysis. Specifically, we obtained gene expression data from unstimulated macrophages (M0) and macrophages stimulated with lipopolysaccharides (LPS) for 2  ...[more]

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