The University of Hong Kong Colon Cancer Organoids Genomics Study Data Access Committee
Ontology highlight
ABSTRACT:
PROVIDER: EGAC00001001405 | EGA |
REPOSITORIES: EGA
Publications
Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles.
Yan Helen H N HHN Siu Hoi Cheong HC Ho Siu Lun SL Yue Sarah S K SSK Gao Yang Y Tsui Wai Yin WY Chan Dessy D Chan April S AS Wong Jason W H JWH Man Alice H Y AHY Lee Bernard C H BCH Chan Annie S Y ASY Chan Anthony K W AKW Hui Ho Sang HS Cheung Arthur K L AKL Law Wai Lun WL Lo Oswens S H OSH Yuen Siu Tsan ST Clevers Hans H Leung Suet Yi SY
Gut 20200326 12
<h4>Objective</h4>Sporadic early-onset colorectal cancer (EOCRC) has bad prognosis, yet is poorly represented by cell line models. We examine the key mutational and transcriptomic alterations in an organoid biobank enriched in EOCRCs.<h4>Design</h4>We established paired cancer (n=32) and normal organoids (n=18) from 20 patients enriched in microsatellite-stable EOCRC. Exome and transcriptome analysis was performed.<h4>Results</h4>We observed a striking diversity of molecular phenotypes, includin ...[more]
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