Dataset Information
DKFZ Medulloblastoma data access committee
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PXD016832
PROVIDER: EGAC00001001844 | EGA |
REPOSITORIES: EGA
Publications
Germline Elongator mutations in Sonic Hedgehog medulloblastoma.
Nature 20200401 7803
Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of many rare cancers remains unclear. Genetic predisposition accounts for 5 to 10% of cancer diagnoses in children<sup>1,2</sup>, and genetic events that cooperate with known somatic driver events are poorly understood. Pathogenic germline variants in established cancer predisposition genes have been recently identified in 5% of patients with the maligna ...[more]
