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Meningene researchers data access committee

ABSTRACT: Data Access Committee EGAC00001002513

PROVIDER: EGAC00001002513 | EGA |

REPOSITORIES: EGA

ACCESS DATA

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Publications

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis.

Lees John A JA Ferwerda Bart B Kremer Philip H C PHC Wheeler Nicole E NE Serón Mercedes Valls MV Croucher Nicholas J NJ Gladstone Rebecca A RA Bootsma Hester J HJ Rots Nynke Y NY Wijmega-Monsuur Alienke J AJ Sanders Elisabeth A M EAM Trzciński Krzysztof K Wyllie Anne L AL Zwinderman Aeilko H AH van den Berg Leonard H LH van Rheenen Wouter W Veldink Jan H JH Harboe Zitta B ZB Lundbo Lene F LF de Groot Lisette C P G M LCPGM van Schoor Natasja M NM van der Velde Nathalie N Ängquist Lars H LH Sørensen Thorkild I A TIA Nohr Ellen A EA Mentzer Alexander J AJ Mills Tara C TC Knight Julian C JC du Plessis Mignon M Nzenze Susan S Weiser Jeffrey N JN Parkhill Julian J Madhi Shabir S Benfield Thomas T von Gottberg Anne A van der Ende Arie A Brouwer Matthijs C MC Barrett Jeffrey C JC Bentley Stephen D SD van de Beek Diederik D

Nature communications 20190515 1

Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. In a genome-wide association study of human and pathogen we show that human variation explains almost half of variation in susceptibility to pneumococcal meningitis and one-third of variation in severity, ide ...[more]

PMID: 31092817

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