Genomics

Dataset Information

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EGAD00000000059


ABSTRACT: Aggregate results from 43 Carbamazepine-induced hypersensitivity syndrome patients and 1296 1958 British Birth Cohort control samples

PROVIDER: EGAD00000000059 | EGA |

REPOSITORIES: EGA

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<h4>Background</h4>Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations.<h4>Methods</h4>We performed a genomewide association study of samples obtained from 22 subjects with carbamaze  ...[more]

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