Genomics

Dataset Information

0

EGAD00000000103


ABSTRACT: Gabriel samples from the Russian UFA cohort

PROVIDER: EGAD00000000103 | EGA |

REPOSITORIES: EGA

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Publications

A large-scale, consortium-based genomewide association study of asthma.

Moffatt Miriam F MF   Gut Ivo G IG   Demenais Florence F   Strachan David P DP   Bouzigon Emmanuelle E   Heath Simon S   von Mutius Erika E   Farrall Martin M   Lathrop Mark M   Cookson William O C M WOCM  

The New England journal of medicine 20100901 13


<h4>Background</h4>Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease.<h4>Methods</h4>We carried out a genomewide association study by genotyping 10,365 persons with physician-diagnosed asthma and 16,110 unaffected perso  ...[more]

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