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EGAD00000000114

ABSTRACT: Whole transcriptome sequence data from 18 ovarian clear-cell carcinoma samples and one TOV21G ovarian clear-cell carcinoma cell line

PROVIDER: EGAD00000000114 | EGA |

REPOSITORIES: EGA

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ARID1A mutations in endometriosis-associated ovarian carcinomas.

Wiegand Kimberly C KC Shah Sohrab P SP Al-Agha Osama M OM Zhao Yongjun Y Tse Kane K Zeng Thomas T Senz Janine J McConechy Melissa K MK Anglesio Michael S MS Kalloger Steve E SE Yang Winnie W Heravi-Moussavi Alireza A Giuliany Ryan R Chow Christine C Fee John J Zayed Abdalnasser A Prentice Leah L Melnyk Nataliya N Turashvili Gulisa G Delaney Allen D AD Madore Jason J Yip Stephen S McPherson Andrew W AW Ha Gavin G Bell Lynda L Fereday Sian S Tam Angela A Galletta Laura L Tonin Patricia N PN Provencher Diane D Miller Dianne D Jones Steven J M SJ Moore Richard A RA Morin Gregg B GB Oloumi Arusha A Boyd Niki N Aparicio Samuel A SA Shih Ie-Ming IeM Mes-Masson Anne-Marie AM Bowtell David D DD Hirst Martin M Gilks Blake B Marra Marco A MA Huntsman David G DG

The New England journal of medicine 20100908 16

<h4>Background</h4>Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described.<h4>Methods</h4>We sequenced the whole transcriptomes of 18 ovarian clear-cell carcinomas and 1 ovarian clear-cell carcinoma cell line and found somatic mutations in ARID1A (the AT-rich interactive domain 1A [SWI-like] gene) in 6 of the samples. ARID1A encodes BAF250a, a key component of the SWI–SNF chromatin remodeling c ...[more]

PMID: 20942669

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