Genomics

Dataset Information

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EGAS00000000092-ega-13012012 - samples

ABSTRACT: Recurrent Somatic Mutations in CLL

PROVIDER: EGAD00001000083 | EGA |

REPOSITORIES: EGA

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Publications

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia.

Ferreira Pedro G PG   Jares Pedro P   Rico Daniel D   Gómez-López Gonzalo G   Martínez-Trillos Alejandra A   Villamor Neus N   Ecker Simone S   González-Pérez Abel A   Knowles David G DG   Monlong Jean J   Johnson Rory R   Quesada Victor V   Djebali Sarah S   Papasaikas Panagiotis P   López-Guerra Mónica M   Colomer Dolors D   Royo Cristina C   Cazorla Maite M   Pinyol Magda M   Clot Guillem G   Aymerich Marta M   Rozman Maria M   Kulis Marta M   Tamborero David D   Gouin Anaïs A   Blanc Julie J   Gut Marta M   Gut Ivo I   Puente Xose S XS   Pisano David G DG   Martin-Subero José Ignacio JI   López-Bigas Nuria N   López-Guillermo Armando A   Valencia Alfonso A   López-Otín Carlos C   Campo Elías E   Guigó Roderic R  

Genome research 20131121 2

Chronic lymphocytic leukemia (CLL) has heterogeneous clinical and biological behavior. Whole-genome and -exome sequencing has contributed to the characterization of the mutational spectrum of the disease, but the underlying transcriptional profile is still poorly understood. We have performed deep RNA sequencing in different subpopulations of normal B-lymphocytes and CLL cells from a cohort of 98 patients, and characterized the CLL transcriptional landscape with unprecedented resolution. We dete  ...[more]

PMID: 24265505

Publication: 1/3

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