Project description:Genome-wide analysis of H3K27me3 occupancy and DNA methylation in
K27M-mutant and H3.3-WT primary pediatric high-grade gliomas (pHGGs)
as well as pediatric pHGG cell lines. The study aims to elucidate the
connection between K27M-induced H3K27me3 reduction and changes in DNA
methylation as well as gene expression.