Dataset Information

EGAS00001000262-sc-20131030 - samples

ABSTRACT: Whole genome DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of 3 men. For each of three different prostates, multiple tumour samples (4, 5, and 3 depending on the case) and one normal tissue sample were whole genome sequenced with a matched blood sample using the Illumiuna HiSeq platform. Tumour samples were sequenced to a target depth of 50X and normals and blood to a target depth of 30X. As of September 2020, some of the studies using these data include: Cooper et al, Nature Genetics 2015 (PMID: 25730763) Wedge et al, Nature Genetics 2018 (PMID: 29662167) Pan-Cancer Analysis of Whole Genomes, Nature 2020 (PMID: 32025007)

PROVIDER: EGAD00001000689 | EGA |

REPOSITORIES: EGA

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Publications

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Wedge David C DC Gundem Gunes G Mitchell Thomas T Woodcock Dan J DJ Martincorena Inigo I Ghori Mohammed M Zamora Jorge J Butler Adam A Whitaker Hayley H Kote-Jarai Zsofia Z Alexandrov Ludmil B LB Van Loo Peter P Massie Charlie E CE Dentro Stefan S Warren Anne Y AY Verrill Clare C Berney Dan M DM Dennis Nening N Merson Sue S Hawkins Steve S Howat William W Lu Yong-Jie YJ Lambert Adam A Kay Jonathan J Kremeyer Barbara B Karaszi Katalin K Luxton Hayley H Camacho Niedzica N Marsden Luke L Edwards Sandra S Matthews Lucy L Bo Valeria V Leongamornlert Daniel D McLaren Stuart S Ng Anthony A Yu Yongwei Y Zhang Hongwei H Dadaev Tokhir T Thomas Sarah S Easton Douglas F DF Ahmed Mahbubl M Bancroft Elizabeth E Fisher Cyril C Livni Naomi N Nicol David D Tavaré Simon S Gill Pelvender P Greenman Christopher C Khoo Vincent V Van As Nicholas N Kumar Pardeep P Ogden Christopher C Cahill Declan D Thompson Alan A Mayer Erik E Rowe Edward E Dudderidge Tim T Gnanapragasam Vincent V Shah Nimish C NC Raine Keiran K Jones David D Menzies Andrew A Stebbings Lucy L Teague Jon J Hazell Steven S Corbishley Cathy C de Bono Johann J Attard Gerhardt G Isaacs William W Visakorpi Tapio T Fraser Michael M Boutros Paul C PC Bristow Robert G RG Workman Paul P Sander Chris C Hamdy Freddie C FC Futreal Andrew A McDermott Ultan U Al-Lazikani Bissan B Lynch Andrew G AG Bova G Steven GS Foster Christopher S CS Brewer Daniel S DS Neal David E DE Cooper Colin S CS Eeles Rosalind A RA

Nature genetics 20180416 5

Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer samples. From joint analysis of these cancers with those from previous studies (930 cancers in total), we found evidence for 22 previously unidentified putative driver genes harboring coding mutations, as well as evidence for NEAT1 and FOXA1 acting as drivers through noncoding mutat ...[more]

PMID: 29662167

Publication: 1/2

Dataset Information

EGAS00001000262-sc-20131030 - samples

Publications

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

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