Dataset Information
Ena-DATASET-BCCA-06-12-2013-17:57:13:627-21 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001000702 | EGA |
REPOSITORIES: EGA
Publications
Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.
Nature medicine 20131222 1
Mantle cell lymphoma (MCL) is an aggressive malignancy that is characterized by poor prognosis. Large-scale pharmacological profiling across more than 100 hematological cell line models identified a subset of MCL cell lines that are highly sensitive to the B cell receptor (BCR) signaling inhibitors ibrutinib and sotrastaurin. Sensitive MCL models exhibited chronic activation of the BCR-driven classical nuclear factor-κB (NF-κB) pathway, whereas insensitive cell lines displayed activation of the ...[more]
