Genomics

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Ena-DATASET-BLUEPRINT-21-02-2014-11:36:11:836-20 - samples

ABSTRACT: Data supporting the paper Transcriptional diversity during lineage commitment of human blood progenitors

PROVIDER: EGAD00001000745 | EGA |

REPOSITORIES: EGA

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Transcriptional diversity during lineage commitment of human blood progenitors.

Chen Lu L   Kostadima Myrto M   Martens Joost H A JHA   Canu Giovanni G   Garcia Sara P SP   Turro Ernest E   Downes Kate K   Macaulay Iain C IC   Bielczyk-Maczynska Ewa E   Coe Sophia S   Farrow Samantha S   Poudel Pawan P   Burden Frances F   Jansen Sjoert B G SBG   Astle William J WJ   Attwood Antony A   Bariana Tadbir T   de Bono Bernard B   Breschi Alessandra A   Chambers John C JC   Consortium Bridge B   Choudry Fizzah A FA   Clarke Laura L   Coupland Paul P   van der Ent Martijn M   Erber Wendy N WN   Jansen Joop H JH   Favier Rémi R   Fenech Matthew E ME   Foad Nicola N   Freson Kathleen K   van Geet Chris C   Gomez Keith K   Guigo Roderic R   Hampshire Daniel D   Kelly Anne M AM   Kerstens Hindrik H D HHD   Kooner Jaspal S JS   Laffan Michael M   Lentaigne Claire C   Labalette Charlotte C   Martin Tiphaine T   Meacham Stuart S   Mumford Andrew A   Nürnberg Sylvia S   Palumbo Emilio E   van der Reijden Bert A BA   Richardson David D   Sammut Stephen J SJ   Slodkowicz Greg G   Tamuri Asif U AU   Vasquez Louella L   Voss Katrin K   Watt Stephen S   Westbury Sarah S   Flicek Paul P   Loos Remco R   Loos Remco R   Goldman Nick N   Bertone Paul P   Read Randy J RJ   Richardson Sylvia S   Cvejic Ana A   Soranzo Nicole N   Ouwehand Willem H WH   Stunnenberg Hendrik G HG   Frontini Mattia M   Rendon Augusto A  

Science (New York, N.Y.) 20140901 6204

Blood cells derive from hematopoietic stem cells through stepwise fating events. To characterize gene expression programs driving lineage choice, we sequenced RNA from eight primary human hematopoietic progenitor populations representing the major myeloid commitment stages and the main lymphoid stage. We identified extensive cell type-specific expression changes: 6711 genes and 10,724 transcripts, enriched in non-protein-coding elements at early stages of differentiation. In addition, we found 7  ...[more]

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