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QCMG_20140410_OESO - samples

ABSTRACT: Description not provided

PROVIDER: EGAD00001000845 | EGA |

REPOSITORIES: EGA

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Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.

Nones Katia K Waddell Nicola N Wayte Nicci N Patch Ann-Marie AM Bailey Peter P Newell Felicity F Holmes Oliver O Fink J Lynn JL Quinn Michael C J MCJ Tang Yue Hang YH Lampe Guy G Quek Kelly K Loffler Kelly A KA Manning Suzanne S Idrisoglu Senel S Miller David D Xu Qinying Q Waddell Nick N Wilson Peter J PJ Bruxner Timothy J C TJC Christ Angelika N AN Harliwong Ivon I Nourse Craig C Nourbakhsh Ehsan E Anderson Matthew M Kazakoff Stephen S Leonard Conrad C Wood Scott S Simpson Peter T PT Reid Lynne E LE Krause Lutz L Hussey Damian J DJ Watson David I DI Lord Reginald V RV Nancarrow Derek D Phillips Wayne A WA Gotley David D Smithers B Mark BM Whiteman David C DC Hayward Nicholas K NK Campbell Peter J PJ Pearson John V JV Grimmond Sean M SM Barbour Andrew P AP

Nature communications 20141029

Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large EAC exome sequencing efforts to date have found recurrent loss-of-function mutations, oncogenic driving events have been underrepresented. Here we use a combination of whole-genome sequencing (WGS) and single-nucleotide polymorphism-array profiling to show that genomic catastrophes are frequent in EAC ...[more]

PMID: 25351503

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