Genomics

Dataset Information

0

EGAS00001000262-sc-20140722 - samples

ABSTRACT: To characterize the subclonal genomic architecture of androgen-deprived metastatic prostate cancer, we performed whole-genome sequencing (WGS) of 51 tumours from 10 patients to an average sequencing depth of 55x, including multiple metastases from different anatomic sites in each patient and, in five cases, the prostate tumour. Noncancerous DNA from blood or other tissue is used as reference comparison for each patient. The patients are part of PELICAN (Project to ELIminate Lethal Cancer) rapid autopsy study led by G. Steven Bova at Johns Hopkins University (USA) and Tampere University (Finland). As of September 2020, some of the studies using these data include: Gundem et al, Nature 2015 (PMID: 25830880). Additional EGAD00001000891 sample metadata is contained in Supplementary Information in this report.Tubio et al, Science 2014 (PMID: 25082706) Behjati et al, Nature Comm 2015 (PMID: 27615322) Wedge et al, Nature Genetics 2018 (PMID: 29662167)Pan-Cancer Analysis of Whole Genomes, Nature 2020 (PMID: 32025007)Rodriguez-Martin et al, Nature Genetics 2020 (PMID: 32024998)Woodcock et al, Nature Comm 2020 (In Press)

PROVIDER: EGAD00001000891 | EGA |

REPOSITORIES: EGA

Json Xml
altmetric image

Publications

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Wedge David C DC   Gundem Gunes G   Mitchell Thomas T   Woodcock Dan J DJ   Martincorena Inigo I   Ghori Mohammed M   Zamora Jorge J   Butler Adam A   Whitaker Hayley H   Kote-Jarai Zsofia Z   Alexandrov Ludmil B LB   Van Loo Peter P   Massie Charlie E CE   Dentro Stefan S   Warren Anne Y AY   Verrill Clare C   Berney Dan M DM   Dennis Nening N   Merson Sue S   Hawkins Steve S   Howat William W   Lu Yong-Jie YJ   Lambert Adam A   Kay Jonathan J   Kremeyer Barbara B   Karaszi Katalin K   Luxton Hayley H   Camacho Niedzica N   Marsden Luke L   Edwards Sandra S   Matthews Lucy L   Bo Valeria V   Leongamornlert Daniel D   McLaren Stuart S   Ng Anthony A   Yu Yongwei Y   Zhang Hongwei H   Dadaev Tokhir T   Thomas Sarah S   Easton Douglas F DF   Ahmed Mahbubl M   Bancroft Elizabeth E   Fisher Cyril C   Livni Naomi N   Nicol David D   Tavaré Simon S   Gill Pelvender P   Greenman Christopher C   Khoo Vincent V   Van As Nicholas N   Kumar Pardeep P   Ogden Christopher C   Cahill Declan D   Thompson Alan A   Mayer Erik E   Rowe Edward E   Dudderidge Tim T   Gnanapragasam Vincent V   Shah Nimish C NC   Raine Keiran K   Jones David D   Menzies Andrew A   Stebbings Lucy L   Teague Jon J   Hazell Steven S   Corbishley Cathy C   de Bono Johann J   Attard Gerhardt G   Isaacs William W   Visakorpi Tapio T   Fraser Michael M   Boutros Paul C PC   Bristow Robert G RG   Workman Paul P   Sander Chris C   Hamdy Freddie C FC   Futreal Andrew A   McDermott Ultan U   Al-Lazikani Bissan B   Lynch Andrew G AG   Bova G Steven GS   Foster Christopher S CS   Brewer Daniel S DS   Neal David E DE   Cooper Colin S CS   Eeles Rosalind A RA  

Nature genetics 20180416 5

Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer samples. From joint analysis of these cancers with those from previous studies (930 cancers in total), we found evidence for 22 previously unidentified putative driver genes harboring coding mutations, as well as evidence for NEAT1 and FOXA1 acting as drivers through noncoding mutat  ...[more]

PMID: 29662167

Publication: 1/2

Similar Datasets

Genomics EGAS00001000262-sc-20141219 - samples
| EGAD00001001116 | EGA
Genomics EGAS00001000262-sc-20131030 - samples
| EGAD00001000689 | EGA
Genomics EGAS00001000262-sc-20140722b - samples
| EGAD00001000892 | EGA
Other Ribosome profiling of MCMV
2023-04-26 | GSE212288 | GEO
Transcriptomics Identifying crossover locations in Arabidopsis thaliana h2a.w7 Col-0 × Ler F2 populations using genotyping-by-sequencing
2025-07-11 | E-MTAB-15040 | biostudies-arrayexpress
Methylation profiling DNMT1 mutant ants develop normally, but have disrupted oogenesis and decreased survival
2023-03-23 | GSE182212 | GEO
Genomics EGAS00001000262-sc-20160408 - samples
| EGAD00001002002 | EGA
Transcriptomics Single-cell RNA-seq of ASPM mutant ferret embryonic forebrain
2018-04-18 | GSE110010 | GEO
Transcriptomics ST105-02: Deciphering and comparison of tumor mutational burden of MBT2 and LM8 mouse cancer cell lines
2024-05-31 | GSE224642 | GEO
Transcriptomics Alternative processing of GTEx RNA-seq data
2017-07-12 | GSE86354 | GEO