Genomics,Multiomics

Dataset Information

0

Ena-DATASET-DKFZ-IBIOS-01-08-2014-15:53:49:885-84 - samples

ABSTRACT: Whole genome bisulfite sequencing data for 6 ependymomas plus 3 fetal controls (f1, f2, f4) and 3 adult controls (a2, a3, a4). See Mack, Witt et al. Nature 506(7489):445-50, 2014 (PMID: 24553142).

OTHER RELATED OMICS DATASETS IN: PRJNA185821PRJNA185826PRJNA185824PRJNA185822PRJNA241314PRJNA185825PRJNA185823PRJNA185827

PROVIDER: EGAD00001000966 | EGA |

REPOSITORIES: EGA

Json Xml
altmetric image

Publications

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.

Mack S C SC   Witt H H   Piro R M RM   Gu L L   Zuyderduyn S S   Stütz A M AM   Wang X X   Wang X X   Gallo M M   Garzia L L   Zayne K K   Zhang X X   Ramaswamy V V   Jäger N N   Jones D T W DT   Sill M M   Pugh T J TJ   Ryzhova M M   Wani K M KM   Shih D J H DJ   Head R R   Remke M M   Bailey S D SD   Zichner T T   Faria C C CC   Barszczyk M M   Stark S S   Seker-Cin H H   Hutter S S   Johann P P   Bender S S   Hovestadt V V   Tzaridis T T   Dubuc A M AM   Northcott P A PA   Peacock J J   Bertrand K C KC   Agnihotri S S   Cavalli F M G FM   Clarke I I   Nethery-Brokx K K   Creasy C L CL   Verma S K SK   Koster J J   Wu X X   Yao Y Y   Milde T T   Sin-Chan P P   Zuccaro J J   Lau L L   Pereira S S   Castelo-Branco P P   Hirst M M   Marra M A MA   Roberts S S SS   Fults D D   Massimi L L   Cho Y J YJ   Van Meter T T   Grajkowska W W   Lach B B   Kulozik A E AE   von Deimling A A   Witt O O   Scherer S W SW   Fan X X   Muraszko K M KM   Kool M M   Pomeroy S L SL   Gupta N N   Phillips J J   Huang A A   Tabori U U   Hawkins C C   Malkin D D   Kongkham P N PN   Weiss W A WA   Jabado N N   Rutka J T JT   Bouffet E E   Korbel J O JO   Lupien M M   Aldape K D KD   Bader G D GD   Eils R R   Lichter P P   Dirks P B PB   Pfister S M SM   Korshunov A A   Taylor M D MD  

Nature 20140219 7489

Ependymomas are common childhood brain tumours that occur throughout the nervous system, but are most common in the paediatric hindbrain. Current standard therapy comprises surgery and radiation, but not cytotoxic chemotherapy as it does not further increase survival. Whole-genome and whole-exome sequencing of 47 hindbrain ependymomas reveals an extremely low mutation rate, and zero significant recurrent somatic single nucleotide variants. Although devoid of recurrent single nucleotide variants  ...[more]

Similar Datasets

Genomics,Multiomics ena-DATASET-DKFZ-IBIOS-30-07-2014-09:26:18:392-401 - samples
| EGAD00001000950 | EGA
Genomics,Multiomics ena-DATASET-DKFZ-IBIOS-30-07-2014-09:29:18:389-402 - samples
| EGAD00001000951 | EGA
Genomics Normal brain controls for ICGC PedBrain DNA methylation sequencing
| EGAS00001000909 | EGA
Transcriptomics Comparison of gene expression profiles by CD3+CD4+ thymocytes derived from fetal and adult hematopoietic stem cells
2010-12-17 | E-GEOD-25085 | biostudies-arrayexpress
Unknown Structure and enzymic activity of ribonuclease-A esterified at glutamic acid-49 and aspartic acid-53.
| S-EPMC1185847 | biostudies-other
no omics defined IGR_EPENDYMOMA_STUDY_MP
2010-12-31 | E-TABM-873 | biostudies-arrayexpress
Transcriptomics Comparative genomic hybridization by array of human intracranial childhood ependymomas at diagnosis and relapse
2011-06-20 | E-TABM-1023 | biostudies-arrayexpress
Methylation profiling Methylation analysis of 81 glioma clinical samples (49 CIMP+ and 32 CIMP-) and 53 cell line samples
2012-02-16 | GSE30338 | GEO
Transcriptomics Methylation analysis of 81 glioma clinical samples (49 CIMP+ and 32 CIMP-) and 53 cell line samples
2012-02-16 | E-GEOD-30338 | biostudies-arrayexpress
Genomics,Multiomics Homo sapiens
| PRJNA93471 | ENA