Dataset Information
Ena-DATASET-CRUK-LRI-05-08-2014-14:10:54:243-46 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001000973 | EGA |
REPOSITORIES: EGA
Publications
Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution.
Genome biology 20140827 8
<h4>Background</h4>Genomic analysis of multi-focal renal cell carcinomas from an individual with a germline VHL mutation offers a unique opportunity to study tumor evolution.<h4>Results</h4>We perform whole exome sequencing on four clear cell renal cell carcinomas removed from both kidneys of a patient with a germline VHL mutation. We report that tumors arising in this context are clonally independent and harbour distinct secondary events exemplified by loss of chromosome 3p, despite an identica ...[more]
