Dataset Information
Ena-DATASET-SC-16-09-2014-14:22:12:125-153 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001001014 | EGA |
REPOSITORIES: EGA
Publications
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer.
eLife 20141001
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mtDNA are unclear. In this study, we analyzed somatic alterations in mtDNA from 1675 tumors. We identified 1907 somatic substitutions, which exhibited dramatic replicative strand bias, predominantly C > T and A > G on the mitochondrial heavy strand. This strand ...[more]
