Dataset Information
Ena-DATASET-DUKE-NUS-15-10-2014-08:01:00:925-302 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001001036 | EGA |
REPOSITORIES: EGA
Publications
Mutation signatures implicate aristolochic acid in bladder cancer development.
Genome medicine 20150428 1
<h4>Background</h4>Aristolochic acid (AA) is a natural compound found in many plants of the Aristolochia genus, and these plants are widely used in traditional medicines for numerous conditions and for weight loss. Previous work has connected AA-mutagenesis to upper-tract urothelial cell carcinomas and hepatocellular carcinomas. We hypothesize that AA may also contribute to bladder cancer.<h4>Methods</h4>Here, we investigated the involvement of AA-mutagenesis in bladder cancer by sequencing blad ...[more]
