Genomics

Dataset Information

0

Ena-DATASET-IJC-07-11-2014-17:58:39:549-794 - samples


ABSTRACT: Cancer exome reads consisting of FASTQ paired end reads from bone marrow samples

OTHER RELATED OMICS DATASETS IN: PRJNA254802

PROVIDER: EGAD00001001058 | EGA |

REPOSITORIES: EGA

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Publications


The casein kinase 1A1 gene (CSNK1A1) is a putative tumor suppressor gene located in the common deleted region for del(5q) myelodysplastic syndrome (MDS). We generated a murine model with conditional inactivation of Csnk1a1 and found that Csnk1a1 haploinsufficiency induces hematopoietic stem cell expansion and a competitive repopulation advantage, whereas homozygous deletion induces hematopoietic stem cell failure. Based on this finding, we found that heterozygous inactivation of Csnk1a1 sensitiz  ...[more]

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