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Plasma DNA aberrations in systemic lupus erythematosus (DNA-seq) - samples

ABSTRACT: Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing

PROVIDER: EGAD00001001093 | EGA |

REPOSITORIES: EGA

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Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing.

Chan Rebecca W Y RW Jiang Peiyong P Peng Xianlu X Tam Lai-Shan LS Liao Gary J W GJ Li Edmund K M EK Wong Priscilla C H PC Sun Hao H Chan K C Allen KC Chiu Rossa W K RW Lo Y M Dennis YM

Proceedings of the National Academy of Sciences of the United States of America 20141126 49

We performed a high-resolution analysis of the biological characteristics of plasma DNA in systemic lupus erythematosus (SLE) patients using massively parallel genomic and methylomic sequencing. A number of plasma DNA abnormalities were found. First, aberrations in measured genomic representations (MGRs) were identified in the plasma DNA of SLE patients. The extent of the aberrations in MGRs correlated with anti-double-stranded DNA (anti-dsDNA) antibody level. Second, the plasma DNA of active SL ...[more]

PMID: 25427797

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