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Ena-DATASET-ICR-PTGT-05-02-2015-11:21:41:591-6 - samples

ABSTRACT: Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.

PROVIDER: EGAD00001001243 | EGA |

REPOSITORIES: EGA

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Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.

Jäger Roland R Migliorini Gabriele G Henrion Marc M Kandaswamy Radhika R Speedy Helen E HE Heindl Andreas A Whiffin Nicola N Carnicer Maria J MJ Broome Laura L Dryden Nicola N Nagano Takashi T Schoenfelder Stefan S Enge Martin M Yuan Yinyin Y Taipale Jussi J Fraser Peter P Fletcher Olivia O Houlston Richard S RS

Nature communications 20150219

Multiple regulatory elements distant from their targets on the linear genome can influence the expression of a single gene through chromatin looping. Chromosome conformation capture implemented in Hi-C allows for genome-wide agnostic characterization of chromatin contacts. However, detection of functional enhancer-promoter interactions is precluded by its effective resolution that is determined by both restriction fragmentation and sensitivity of the experiment. Here we develop a capture Hi-C (c ...[more]

PMID: 25695508

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