Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Ena-DATASET-UKBEC-12-03-2015-16:21:20:556-32 - samples

ABSTRACT: Brain samples for this dataset were provided by the Medical Research Council Sudden Death Brain and Tissue Bank (Edinburgh, UK). All four individuals sampled were of European descent, neurologically normal during life and confirmed to be neuropathologically normal by a consultant neuropathologist using histology performed on sections prepared from paraffin-embedded tissue blocks. Twelve regions of the central nervous system were sampled from each individual. The regions studied were: cerebellar cortex, frontal cortex, temporal cortex, occipital cortex, hippocampus, the inferior olivary nucleus (sub-dissected from the medulla), putamen, substantia nigra, thalamus, hypothalamus, intralobular white matter and cervical spinal cord.

PROVIDER: EGAD00001001274 | EGA |

REPOSITORIES: EGA

ACCESS DATA

Json Xml

Publications

Recursive splicing in long vertebrate genes.

Sibley Christopher R CR Emmett Warren W Blazquez Lorea L Faro Ana A Haberman Nejc N Briese Michael M Trabzuni Daniah D Ryten Mina M Weale Michael E ME Hardy John J Modic Miha M Curk Tomaž T Wilson Stephen W SW Plagnol Vincent V Ule Jernej J

Nature 20150513 7552

It is generally believed that splicing removes introns as single units from precursor messenger RNA transcripts. However, some long Drosophila melanogaster introns contain a cryptic site, known as a recursive splice site (RS-site), that enables a multi-step process of intron removal termed recursive splicing. The extent to which recursive splicing occurs in other species and its mechanistic basis have not been examined. Here we identify highly conserved RS-sites in genes expressed in the mammali ...[more]

PMID: 25970246

Similar Datasets

Expression data generated from post-mortem human brain tissue originating from neurologically and neuropathologically control individuals

Project description:This is a subset of the data set generated by the UK Brain Expression Consortium. This subset has been used specifically to study the effects of age on gene expression in multiple human tissues, and all samples originate from a single brain bank, the MRC Sudden Death Brain and Tissue Bank in Edinburgh. The UK Brain Expression Consortium has generated gene expression data on a large cohort of neurologically and neuropathologically normal individuals in order to better understand gene expression differences across the human brain. 932 samples are analysed in total originating from 100 Caucasian individuals. From each individual, up to ten brain regions were sampled and analysed.

2013-06-27 | E-GEOD-46706 | biostudies-arrayexpress

Gene-level analysis of 1231 samples originating from 134 Caucasian individuals

Project description:This data set was generated by the UK Brain Expression Consortium and consists of gene expression data generated from post-mortem human brain samples, dissected from 10 brain regions and originating from a large cohort of neurologically and neuropathologically normal individuals. The UK Brain Expression Consortium has generated gene expression data on a large cohort of neurologically and neuropathologically normal individuals in order to better understand gene expression differences across the human brain. 1231 samples are analysed in total and these samples originate from 134 Caucasian individuals. From each individual, up to ten brain regions were sampled and analysed.

2014-08-29 | E-GEOD-60862 | biostudies-arrayexpress

Exon-level analysis of 1231 samples originating from 134 Caucasian individuals

2014-08-29 | E-GEOD-60863 | biostudies-arrayexpress

Exon-level analysis of 1231 samples originating from 134 Caucasian individuals

2014-08-29 | GSE60863 | GEO

Gene-level analysis of 1231 samples originating from 134 Caucasian individuals

2014-08-29 | GSE60862 | GEO

Expression data generated from post-mortem human brain tissue originating from neurologically and neuropathologically control individuals

Project description:This data set was generated by the UK Brain Expression Consortium and consists of gene expression data generated from post-mortem human brain samples, dissected from 10 brain regions and originating from a large cohort of neurologically and neuropathologically normal individuals. The UK Brain Expression Consortium has generated gene expression data on a large cohort of neurologically and neuropathologically normal individuals in order to better understand gene expression differences across the human brain. This SuperSeries is composed of the SubSeries listed below.

2013-06-27 | GSE46706 | GEO

Identification and analysis of short open reading frame encoded peptides in different brain regions of mice

Project description:Here we used mass spectrometry-based proteomics technology to explore SEPs with potential function in five brain regions of the mouse. SEPs with unique peptides were identified in hippocampus, frontal cortex, temporal cortex, occipital cortex and parietal cortex.

2022-08-16 | PXD036064 | iProX

DNA methylation levels of various brain regions from HIV+ and HIV- subjects

Project description:Genome wide DNA methylation profiles of various human brain regions (cerebellum, occipital lobe, etc). The Illumina Infinium 450k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 480,000 CpGs. The dataset includes 130 samples. Multiple brain regions were assessed per subject. The goal was to evaluate the effect of HIV infection on DNA methylation levels. Genome wide DNA methylation profiles of various brain regions from HIV positive and negative subjects. The Illumina Infinium 450k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 480,000 CpGs. Dataset included 130 samples: 99 samples from HIV+ subjects and 31 samples from HIV- subjects. The Illumina Infinium450 platform was applied to various brain regions from HIV+ and HIV- subjects. We evaluated 130 brain samples from 84 different subjects. Specifically, we considered cerebellum (20 HIV+ samples and 4 controls), frontal lobe (2 cases, 4 controls), hippocampus (4 controls), medial frontal cortex (18 cases), occipital cortex (59 cases, 13 controls), temporal cortex (4 controls). In total, there were 99 samples from HIV+ subjects and 31 samples from HIV- controls of similar ages. The subjects were recruited from the National Neurological AIDS Bank study or Multicenter AIDS Cohort study in Los Angeles. Informed consent and all study procedures were approved by the UCLA Medical IRB. DNAm data from HIV+ cases and HIV- controls were generated at the same time and randomized across plates and chips. HIV viral load information was available for blood (measured at the last blood draw) and for cerebrospinal fluid (CSF).

2015-06-09 | E-GEOD-59457 | biostudies-arrayexpress

DNA methylation profiles of human brain tissue samples

Project description:The main goal of the study was to measure the epigenetic age (also known as DNA methylation age) of human tissues and to relate it to chronological age. Toward this end, we used the epigenetic clock software described in Horvath S (n=2013) DNA methylation age of human tissues and cell types. Genome Biology.2013, 14:R115. DOI: 10.1186/10.1186/gb-2013-14-10-r115 PMID: 24138928 Human DNA methylation Beadchip v1.2 was used to obtain n=260 Illumina DNA methylation array from the following human Brain regions: caudate nucleus (n=n=12), cingulate gyrus (n=n12), cerebellum (n=32), frontal cortex (n=41), hippocampus (n=25), midBrain (n=18), motor cortex (n=33), occipital cortex (n=33), parietal lobe (n=23), sensory cortex (n=12), temporal cortex (n=29), visual cortex (n=11).

2015-06-03 | E-GEOD-64509 | biostudies-arrayexpress

Towards a human brain EV atlas: Characteristics of EVs from different brain regions, including small RNA and protein profiles

Project description:Brain derived EVs (bdEVs) from eight brain regions, including orbitofrontal gyrus(ORB), postcentral gyrus (POSTC), hippocampus (HIPPO), thalamus (THAL), occipital gyrus (OCC), medulla (MED), corpus callosum (CORP), and cerebellum (CBLM) were separated and characterized by small RNA sequencing. We aim to provide an atlas of bdEV molecular profiles with brain region specificity.

2023-08-07 | GSE226490 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data