Dataset Information
Ena-DATASET-MGH-CC-08-07-2015-20:42:52:693-393 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001001436 | EGA |
REPOSITORIES: EGA
Publications
RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer.
Nature communications 20150311
Tyrosine kinase inhibitors are effective treatments for non-small-cell lung cancers (NSCLCs) with epidermal growth factor receptor (EGFR) mutations. However, relapse typically occurs after an average of 1 year of continuous treatment. A fundamental histological transformation from NSCLC to small-cell lung cancer (SCLC) is observed in a subset of the resistant cancers, but the molecular changes associated with this transformation remain unknown. Analysis of tumour samples and cell lines derived f ...[more]
