Genomics

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Ena-DATASET-DKFZ-IBIOS-28-08-2015-09:49:06:632-229 - samples

ABSTRACT: RNA-sequencing data from teh hT-RPE-MycER cell line after MYC activation and after MINCR knock-down in conditions of MYC ON or OFF

PROVIDER: EGAD00001001598 | EGA |

REPOSITORIES: EGA

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Publications

MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells.

Doose Gero G   Haake Andrea A   Bernhart Stephan H SH   López Cristina C   Duggimpudi Sujitha S   Wojciech Franziska F   Bergmann Anke K AK   Borkhardt Arndt A   Burkhardt Birgit B   Claviez Alexander A   Dimitrova Lora L   Haas Siegfried S   Hoell Jessica I JI   Hummel Michael M   Karsch Dennis D   Klapper Wolfram W   Kleo Karsten K   Kretzmer Helene H   Kreuz Markus M   Küppers Ralf R   Lawerenz Chris C   Lenze Dido D   Loeffler Markus M   Mantovani-Löffler Luisa L   Möller Peter P   Ott German G   Richter Julia J   Rohde Marius M   Rosenstiel Philip P   Rosenwald Andreas A   Schilhabel Markus M   Schneider Markus M   Scholz Ingrid I   Stilgenbauer Stephan S   Stunnenberg Hendrik G HG   Szczepanowski Monika M   Trümper Lorenz L   Weniger Marc A MA   Hoffmann Steve S   Siebert Reiner R   Iaccarino Ingram I  

Proceedings of the National Academy of Sciences of the United States of America 20150908 38

Despite the established role of the transcription factor MYC in cancer, little is known about the impact of a new class of transcriptional regulators, the long noncoding RNAs (lncRNAs), on MYC ability to influence the cellular transcriptome. Here, we have intersected RNA-sequencing data from two MYC-inducible cell lines and a cohort of 91 B-cell lymphomas with or without genetic variants resulting in MYC overexpression. We identified 13 lncRNAs differentially expressed in IG-MYC-positive Burkitt  ...[more]

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