Dataset Information
Ena-DATASET-JHUSM-16-11-2015-19:53:19:325-4 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001001674 | EGA |
REPOSITORIES: EGA
Publications
The genomic landscape of response to EGFR blockade in colorectal cancer.
Nature 20150930 7572
Colorectal cancer is the third most common cancer worldwide, with 1.2 million patients diagnosed annually. In late-stage colorectal cancer, the most commonly used targeted therapies are the monoclonal antibodies cetuximab and panitumumab, which prevent epidermal growth factor receptor (EGFR) activation. Recent studies have identified alterations in KRAS and other genes as likely mechanisms of primary and secondary resistance to anti-EGFR antibody therapy. Despite these efforts, additional mechan ...[more]
