Genomics

Dataset Information

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Ena-DATASET-UCL-ICH-25-11-2015-12:32:35:398-26 - samples

ABSTRACT: Description not provided

PROVIDER: EGAD00001001687 | EGA |

REPOSITORIES: EGA

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Publications

Telomerase activation by genomic rearrangements in high-risk neuroblastoma.

Peifer Martin M   Hertwig Falk F   Roels Frederik F   Dreidax Daniel D   Gartlgruber Moritz M   Menon Roopika R   Krämer Andrea A   Roncaioli Justin L JL   Sand Frederik F   Heuckmann Johannes M JM   Ikram Fakhera F   Schmidt Rene R   Ackermann Sandra S   Engesser Anne A   Kahlert Yvonne Y   Vogel Wenzel W   Altmüller Janine J   Nürnberg Peter P   Thierry-Mieg Jean J   Thierry-Mieg Danielle D   Mariappan Aruljothi A   Heynck Stefanie S   Mariotti Erika E   Henrich Kai-Oliver KO   Gloeckner Christian C   Bosco Graziella G   Leuschner Ivo I   Schweiger Michal R MR   Savelyeva Larissa L   Watkins Simon C SC   Shao Chunxuan C   Bell Emma E   Höfer Thomas T   Achter Viktor V   Lang Ulrich U   Theissen Jessica J   Volland Ruth R   Saadati Maral M   Eggert Angelika A   de Wilde Bram B   Berthold Frank F   Peng Zhiyu Z   Zhao Chen C   Shi Leming L   Ortmann Monika M   Büttner Reinhard R   Perner Sven S   Hero Barbara B   Schramm Alexander A   Schulte Johannes H JH   Herrmann Carl C   O'Sullivan Roderick J RJ   Westermann Frank F   Thomas Roman K RK   Fischer Matthias M  

Nature 20151014 7575

Neuroblastoma is a malignant paediatric tumour of the sympathetic nervous system. Roughly half of these tumours regress spontaneously or are cured by limited therapy. By contrast, high-risk neuroblastomas have an unfavourable clinical course despite intensive multimodal treatment, and their molecular basis has remained largely elusive. Here we have performed whole-genome sequencing of 56 neuroblastomas (high-risk, n = 39; low-risk, n = 17) and discovered recurrent genomic rearrangements affectin  ...[more]

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