Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001001940 | EGA |
REPOSITORIES: EGA

Hedegaard Jakob J Lamy Philippe P Nordentoft Iver I Algaba Ferran F Høyer Søren S Ulhøi Benedicte Parm BP Vang Søren S Reinert Thomas T Hermann Gregers G GG Mogensen Karin K Thomsen Mathilde Borg Houlberg MBH Nielsen Morten Muhlig MM Marquez Mirari M Segersten Ulrika U Aine Mattias M Höglund Mattias M Birkenkamp-Demtröder Karin K Fristrup Niels N Borre Michael M Hartmann Arndt A Stöhr Robert R Wach Sven S Keck Bastian B Seitz Anna Katharina AK Nawroth Roman R Maurer Tobias T Tulic Cane C Simic Tatjana T Junker Kerstin K Horstmann Marcus M Harving Niels N Petersen Astrid Christine AC Calle M Luz ML Steyerberg Ewout W EW Beukers Willemien W van Kessel Kim E M KEM Jensen Jørgen Bjerggaard JB Pedersen Jakob Skou JS Malmström Per-Uno PU Malats Núria N Real Francisco X FX Zwarthoff Ellen C EC Ørntoft Torben Falck TF Dyrskjøt Lars L
Cancer cell 20160616 1
Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas and showed that NMIBC can be subgrouped into three major classes with basal- and luminal-like characteristics and different clinical outcomes. Large differences in biological processes such as the cell cycle, epithelial-mesenchymal transition, and differentiation were observed. Analysis of transcript v ...[more]