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Ena-DATASET-DKFZ-IBIOS-12-04-2016-13:32:15:134-286 - samples

ABSTRACT: RNA sequencing data of whole blood samples from smoking and non-smoking mothers and their children at gestation/birth and follow-up years.

PROVIDER: EGAD00001002011 | EGA |

REPOSITORIES: EGA

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Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children.

Bauer Tobias T Trump Saskia S Ishaque Naveed N Thürmann Loreen L Gu Lei L Bauer Mario M Bieg Matthias M Gu Zuguang Z Weichenhan Dieter D Mallm Jan-Philipp JP Röder Stefan S Herberth Gunda G Takada Eiko E Mücke Oliver O Winter Marcus M Junge Kristin M KM Grützmann Konrad K Rolle-Kampczyk Ulrike U Wang Qi Q Lawerenz Christian C Borte Michael M Polte Tobias T Schlesner Matthias M Schanne Michaela M Wiemann Stefan S Geörg Christina C Stunnenberg Hendrik G HG Plass Christoph C Rippe Karsten K Mizuguchi Junichiro J Herrmann Carl C Eils Roland R Lehmann Irina I

Molecular systems biology 20160324 3

Epigenetic mechanisms have emerged as links between prenatal environmental exposure and disease risk later in life. Here, we studied epigenetic changes associated with maternal smoking at base pair resolution by mapping DNA methylation, histone modifications, and transcription in expectant mothers and their newborn children. We found extensive global differential methylation and carefully evaluated these changes to separate environment associated from genotype-related DNA methylation changes. Di ...[more]

PMID: 27013061

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