Genomics

Dataset Information

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Ena-DATASET-DKFZ-HIPO-22-04-2016-18:03:44:927-11 - samples

ABSTRACT: Whole exome sequencing from matched tumor-control samples of 121 primary lymphoma samples. Sequencing was performed on Illumina HiSeq2000. The dataset contains FASTQ files.

PROVIDER: EGAD00001002055 | EGA |

REPOSITORIES: EGA

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Publications

Drug-perturbation-based stratification of blood cancer.

Dietrich Sascha S   Oleś Małgorzata M   Lu Junyan J   Sellner Leopold L   Anders Simon S   Velten Britta B   Wu Bian B   Hüllein Jennifer J   da Silva Liberio Michelle M   Walther Tatjana T   Wagner Lena L   Rabe Sophie S   Ghidelli-Disse Sonja S   Bantscheff Marcus M   Oleś Andrzej K AK   Słabicki Mikołaj M   Mock Andreas A   Oakes Christopher C CC   Wang Shihui S   Oppermann Sina S   Lukas Marina M   Kim Vladislav V   Sill Martin M   Benner Axel A   Jauch Anna A   Sutton Lesley Ann LA   Young Emma E   Rosenquist Richard R   Liu Xiyang X   Jethwa Alexander A   Lee Kwang Seok KS   Lewis Joe J   Putzker Kerstin K   Lutz Christoph C   Rossi Davide D   Mokhir Andriy A   Oellerich Thomas T   Zirlik Katja K   Herling Marco M   Nguyen-Khac Florence F   Plass Christoph C   Andersson Emma E   Mustjoki Satu S   von Kalle Christof C   Ho Anthony D AD   Hensel Manfred M   Dürig Jan J   Ringshausen Ingo I   Zapatka Marc M   Huber Wolfgang W   Zenz Thorsten T  

The Journal of clinical investigation 20171211 1

As new generations of targeted therapies emerge and tumor genome sequencing discovers increasingly comprehensive mutation repertoires, the functional relationships of mutations to tumor phenotypes remain largely unknown. Here, we measured ex vivo sensitivity of 246 blood cancers to 63 drugs alongside genome, transcriptome, and DNA methylome analysis to understand determinants of drug response. We assembled a primary blood cancer cell encyclopedia data set that revealed disease-specific sensitivi  ...[more]

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