Dataset Information
Ena-DATASET-SC-15-06-2016-10:23:08:608-358 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001002191 | EGA |
REPOSITORIES: EGA
Publications
Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts.
EMBO molecular medicine 20150901 9
The development of targeted inhibitors, like vemurafenib, has greatly improved the clinical outcome of BRAF(V600E) metastatic melanoma. However, resistance to such compounds represents a formidable problem. Using whole-exome sequencing and functional analyses, we have investigated the nature and pleiotropy of vemurafenib resistance in a melanoma patient carrying multiple drug-resistant metastases. Resistance was caused by a plethora of mechanisms, all of which reactivated the MAPK pathway. In ad ...[more]
