Project description:A new genome of Fraxinus excelsior (PRJNA865134) was assembled using a hybrid approach combining Nanopore and Illumina data. The gene expression of a 182 Danish tree panel (Harper et al. 2016) was assessed using the new genome as reference (BioProject PRJNA865134, SAMN30100368, genome JANJPF000000000 ).Manuscript title: Fraxinus excelsior updated long-read genome reveals the importance of MADS-box genes in tolerance mechanisms against ash dieback, G3:Genes|Genomes|Genetics

2025-03-03 | GSE214551 | GEO

Prevention of early-onset cardiomyopathy in <i>Dmd</i> exon 52-54 deletion mice by CRISPR-Cas9-mediated exon skipping.

Project description: Not available

| S-EPMC10403712 | biostudies-literature

Streptococcus sobrinus TCI-54

Project description:Sequencing clinical isolates from dental plaque

| PRJNA71885 | ENA

ena-DATASET-ICR-18-08-2016-18:34:21:662-52 - samples

Project description:Presurgical studies allow study of the relationship between mutations and response of estrogen receptor positive (ER+) breast cancer to aromatase inhibitors (AIs) but have been limited to small biopsies. Here in Phase I of this study, we perform exome sequencing on baseline, surgical core-cuts and blood from 60 patients (40 AI treated, 20 Controls). In poor responders (based on Ki67 change) we find significantly more somatic mutations than good responders. Subclones exclusive to baseline or surgical cores occur in approximately 30% of tumours. In Phase II we combine targeted sequencing on another 28 treated patients with Phase I. We find six genes frequently mutated: PIK3CA, TP53, CDH1, MLL3, ABCA13 and FLG with 71% concordance between paired cores. TP53 mutations are associated with poor response. We conclude that multiple biopsies are essential for confident mutational profiling of ER+ breast cancer and TP53 mutations are associated with resistance to oestrogen deprivation therapy.

| EGAD00001002651 | EGA

North American historical monthly spatial climate dataset, 1901-2016.

Project description: Not available

| S-EPMC7683623 | biostudies-literature

ENA-pilot

Project description:SARS-CoV-2 datashare

| PRJEB48025 | ENA