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Ewing sarcoma tumors - RRBS - samples

ABSTRACT: RRBS data of 86 Ewing patients (French). Illumina HiSeq 2000/2500 (Fastq files available). Sheffield et al. Nat Med. 2017 Jan 30

PROVIDER: EGAD00001003133 | EGA |

REPOSITORIES: EGA

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DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.

Sheffield Nathan C NC Pierron Gaelle G Klughammer Johanna J Datlinger Paul P Schönegger Andreas A Schuster Michael M Hadler Johanna J Surdez Didier D Guillemot Delphine D Lapouble Eve E Freneaux Paul P Champigneulle Jacqueline J Bouvier Raymonde R Walder Diana D Ambros Ingeborg M IM Hutter Caroline C Sorz Eva E Amaral Ana T AT de Álava Enrique E Schallmoser Katharina K Strunk Dirk D Rinner Beate B Liegl-Atzwanger Bernadette B Huppertz Berthold B Leithner Andreas A de Pinieux Gonzague G Terrier Philippe P Laurence Valérie V Michon Jean J Ladenstein Ruth R Holter Wolfgang W Windhager Reinhard R Dirksen Uta U Ambros Peter F PF Delattre Olivier O Kovar Heinrich H Bock Christoph C Tomazou Eleni M EM

Nature medicine 20170130 3

Developmental tumors in children and young adults carry few genetic alterations, yet they have diverse clinical presentation. Focusing on Ewing sarcoma, we sought to establish the prevalence and characteristics of epigenetic heterogeneity in genetically homogeneous cancers. We performed genome-scale DNA methylation sequencing for a large cohort of Ewing sarcoma tumors and analyzed epigenetic heterogeneity on three levels: between cancers, between tumors, and within tumors. We observed consistent ...[more]

PMID: 28134926

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Expression profiling of Ewing sarcoma samples

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Project description:Ewing sarcoma cell lines

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