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Ena-DATASET-DKFZ-IBIOS-23-03-2017-11:23:22:013-79 - samples

ABSTRACT: Whole genome sequencing for 131 early onset prostate tumor/control pairs (ICGC)

PROVIDER: EGAD00001003256 | EGA |

REPOSITORIES: EGA

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ena-DATASET-DKFZ-IBIOS-13-04-2017-10:50:46:993-399 - samples

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The ERG-regulated LINC00920 promotes prostate cancer cell survival via the 14-3-3ε- FOXO pathway

Project description:LINC00920 is a tumor-associated lncRNA identified in the transcriptome dataset of the International Cancer Genome Consortium-Early Onset Prostate Cancer (ICGC-EOPC) cohort. SiRNA-mediated knockdown of LINC00920 negatively affected proliferation, colony formation, and migration of PC-3 prostate cancer cells. Genome-wide expression profiling was performed to identify cellular pathways affected by LINC00920.

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11-[(E)-Benzyl-idene]-14-hy-droxy-8-phenyl-3,13-diaza-hepta-cyclo-[13.7.1.1.0.0.0.0]tetra-cosa-1(22),15,17,19(23),20-pentaen-10-one.

Project description:In the title compound, C(35)H(30)N(2)O(2), the piperidine ring adopts a chair conformation and the pyrrolidine ring adopts an envelope conformation. The naphthalene ring makes dihedral angles of 24.56 (3) and 36.13 (4)° with the terminal phenyl rings. The dihedral angle between the two terminal phenyl rings is 55.27 (5)°. One of the C atoms in the pyrrolidine ring is disordered over two sites, with a refined occupany ratio of 0.670 (3):0.330 (3). An intra-molecular O-H⋯N hydrogen bond generates an S(6) ring. In the crystal structure, inversion dimers linked by pairs of C-H⋯O hydrogen bonds generate R(2) (2)(18) loops within sheets of mol-ecules lying parallel to the bc plane.

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(E)-(25S)-23-Acetyl-5?-furost-22-ene-3?,26-diol.

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