Genomics

Dataset Information

0

MELA-AU_WXS_20170516 - samples

ABSTRACT: Aligned, merged and deduplicated BAM files from HiSeq whole exome sequencing of 106 samples: matched tumour-normal pairs from 53 melanoma patients.

PROVIDER: EGAD00001003357 | EGA |

REPOSITORIES: EGA

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Publications

Whole-genome landscapes of major melanoma subtypes.

Hayward Nicholas K NK   Wilmott James S JS   Waddell Nicola N   Johansson Peter A PA   Field Matthew A MA   Nones Katia K   Patch Ann-Marie AM   Kakavand Hojabr H   Alexandrov Ludmil B LB   Burke Hazel H   Jakrot Valerie V   Kazakoff Stephen S   Holmes Oliver O   Leonard Conrad C   Sabarinathan Radhakrishnan R   Mularoni Loris L   Wood Scott S   Xu Qinying Q   Waddell Nick N   Tembe Varsha V   Pupo Gulietta M GM   De Paoli-Iseppi Ricardo R   Vilain Ricardo E RE   Shang Ping P   Lau Loretta M S LMS   Dagg Rebecca A RA   Schramm Sarah-Jane SJ   Pritchard Antonia A   Dutton-Regester Ken K   Newell Felicity F   Fitzgerald Anna A   Shang Catherine A CA   Grimmond Sean M SM   Pickett Hilda A HA   Yang Jean Y JY   Stretch Jonathan R JR   Behren Andreas A   Kefford Richard F RF   Hersey Peter P   Long Georgina V GV   Cebon Jonathan J   Shackleton Mark M   Spillane Andrew J AJ   Saw Robyn P M RPM   López-Bigas Núria N   Pearson John V JV   Thompson John F JF   Scolyer Richard A RA   Mann Graham J GJ  

Nature 20170503 7653

Melanoma of the skin is a common cancer only in Europeans, whereas it arises in internal body surfaces (mucosal sites) and on the hands and feet (acral sites) in people throughout the world. Here we report analysis of whole-genome sequences from cutaneous, acral and mucosal subtypes of melanoma. The heavily mutated landscape of coding and non-coding mutations in cutaneous melanoma resolved novel signatures of mutagenesis attributable to ultraviolet radiation. However, acral and mucosal melanomas  ...[more]

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